The San Francisco Giants and the Cincinnati Reds meet Wednesday in MLB action from Great American Ballpark. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Cincinnati Reds prediction.
Starting Pitching Matchup
The San Francisco Giants will send out Tyler Mahle for the start here and Mahle is 0-2 with a 4.30 ERA and 15 strikeouts this season. This will be Mahle’s first career start against the Reds. Rhett Lowder will get the start for Cincinnati and is 1-1 with a 3.31 ERA and 11 strikeouts this season. This will be Lowder’s first career start against the Giants.
San Francisco Giants Recap
The San Francisco Giants come into this game looking to bounce back from a 2-1 loss at the hands of the Reds to sit at 6-11 this season. After this set, the Giants will head on the road for a series against the Washington Nationals.
Giants Lose 3 In A Row
Going into Tuesday’s matchup, Luis Arraez has 17 hits with a double, 2 triples and 6 RBIs while Willy Adames has 16 hits with 9 doubles, 2 home runs and 5 RBIs. Matt Chapman has 3 doubles, a triple, a home run and 7 RBIs and Harrison Bader has a home run and 3 RBIs while Jung Hoo Lee has 10 hits with 4 doubles and a team-high 7 RBIs. Heliot Ramos has 14 hits with 2 doubles and 6 RBIs but also has a team-high 22 strikeouts this season. Rafael Devers also has 14 hits with a double, 2 home runs and 6 RBIs.
Cincinnati Reds Recap
The Cincinnati Reds come into this game looking to add on to their win over San Francisco on Tuesday to sit at 10-7 on the year. After this series, the Reds will head on the road for a set against the Minnesota Twins.
Reds Alternate Wins & Losses In 4 Straight
Entering Tuesday, Sal Stewart has 17 hits with 4 doubles, 4 home runs, 10 RBIs and a .309 batting average while Elly De La Cruz has 18 hits with 3 doubles, 5 home runs and 10 RBIs. Matt McLain’s added 13 hits with 3 doubles and 3 RBIs and Eugenio Suarez has 13 hits with a double, 2 homers and 8 RBIs as well on the year.
San Francisco Giants @ Cincinnati Reds Betting Trends: April 15, 2026
- Probable Starting Pitcher: Rhett Lowder Record this season: 1-1 ERA: 3.31
- Home Record: 0-0
- Last 5 against Giants: –
Why the Cincinnati Reds will win
- The Giants have lost each of their last eight night games against the Reds following a road loss.
- The Reds have won five of their last seven games as home underdogs against NL West opponents.
- The Giants have failed to cover the run line in 15 of their last 17 games as favorites against National League opponents following a loss.
- The Reds have covered the run line in each of their last five night games against the Giants following a home win.
- The Giants have trailed after 5 innings in each of their last four games at Great American Ball Park against opponents that held a winning record.
- The Giants have trailed after 3 innings in each of their last four games at Great American Ball Park against opponents that held a winning record.
- Probable Starting Pitcher: Tyler Mahle Record this season: 0-2 ERA: 4.30
- Road Record: 0-0
- Last 5 against Reds: –
Why the San Francisco Giants will win
- The Giants have won each of their last 12 Wednesday night games as road favorites against National League opponents.
- The Reds have lost each of their last four night games against NL West opponents following a home win.
- The Giants have covered the run line in each of their last eight road games against NL Central opponents following a loss.
- The Reds have failed to cover the run line in eight of their last nine games against teams that held a losing record.
- The Reds have trailed after 5 innings in eight of their last nine games as underdogs against National League opponents.
- The Reds have lost the first inning in three of their last four games against NL West opponents that held a losing record.
- The Giants have led after 3 innings in nine of their last 11 night games against opponents that held a winning record.
Total Runs Facts
- Each of the Reds’ last six games after playing the previous day have gone OVER the total runs line.
- Six of the Giants’ last seven night games after playing the previous day have gone OVER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last seven night games at Great American Ball Park.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Giants’ last nine games at Great American Ball Park.
Cincinnati Reds Player Prop Facts
- Spencer Steer has hit a home run in each of the Reds’ last two games against NL West opponents that held a losing record.
- Elly De La Cruz has recorded at least one hit in each of the Reds’ last 11 night games against NL opponents that held a losing record.
- Sal Stewart ranks 7th amongst qualified players for Slugging Percentage (.638) this season.
San Francisco Giants Player Prop Facts
- Willy Adames has hit a home run in four of his last five road appearances against the Reds after playing the previous day.
- Tyler Mahle has recorded five or more strikeouts in nine of his last 10 appearances at Great American Ball Park.
- Heliot Ramos has recorded at least one hit in each of his last 10 appearances with the Giants as road favorites.
- Tyler Mahle has recorded a win in four of his last five appearances in night games against teams that held a winning record.
- Luis Arraez ranks T8th amongst qualified players for Batting Average (.333) this season.
Matchup/League Facts
- The Reds rank 29th in the league for hits this season (112).
- The Reds rank T29th in the league for doubles this season (17).
- The Giants rank 30th in the league for runs scored this season (52).
- The Giants rank 30th in the league for home runs this season (9).
San Francisco Giants vs. Cincinnati Reds Prediction
I’m on the Reds in this one. I’m not a fan of Tyler Mahle and Mahle struggled in this ballpark for the better portion of a few years when he was with the Reds and now going back I think this Cincinnati lineup gets to him. Lowder’s been solid out of the gate and I think they take care of business here. Give me Cincinnati.