Cleveland Guardians vs Chicago Cubs Prediction 4/3/26 MLB Picks Today

The Chicago Cubs and the Cleveland Guardians meet Friday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Chicago Cubs did not have a starting pitcher announced at the time that this article was posted. The Cleveland Guardians will send out Joey Cantillo for the start here and Cantillo is 0-0 with a 4.91 ERA and 5 strikeouts this season. This will be Cantillo’s second career start against the Cubs.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their 6-2 win over the Angels last time out to improve to 3-3 this season. After this series, Chicago will head on the road again for a series against the Tampa Bay Rays.

Cubs Alternate Wins & Losses In Each Of Their First 6 Games

Ian Happ has 5 hits with a double and a team-high 3 home runs and 5 RBIs while Alex Bregman has 5 hits with 2 home runs and 3 RBIs. Nico Hoerner’s added 7 hits with 4 doubles and 3 RBIs and Moises Ballesteros has 6 hits with a pair of doubles. Pete Crow-Armstrong’s also added 6 hits with 3 RBIs as well on the year. 

Why the Chicago Cubs will win

Chicago Cubs Player Prop Facts

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to a 4-1 win over the Dodgers last time out to improve to 4-3 on the year. After this series, the Guardians will host the Royals at home in a division series.

Guardians Also Looking For Consistency

Chase DeLauter has 6 hits with a team-high 4 home runs and 5 RBIs while Steven Kwan has a team-high 7 hits with a double and Jose Ramirez has 4 hits with 2 doubles, a home run and 5 RBIs this season. Brayan Rocchi has also added 4 hits with a double and 3 RBIs this season.

Why the Cleveland Guardians will win

Cleveland Guardians Player Prop Facts

Total Runs Facts

Chicago Cubs vs. Cleveland Guardians Prediction

I’m leaning towards the Guardians here, it would be interesting to see who the Cubs send out here, but the thing for me in this game is that the Guardians get their home opener here finally, and this is a Guardians team that historically has played well at home. And despite the absences, I still think the Guardians have a solid bullpen when we get to the later stages of the game. All in all, I like the Guardians to draw first blood.

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