The Houston Astros and the Cleveland Guardians meet Tuesday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Cleveland Guardians prediction.
Starting Pitching Matchup
The Houston Astros will send out Ryan Weiss here and Weiss is 0-2 with a 6.75 ERA and 18 strikeouts this season. This will be Weiss’ first career start against the Guardians. Parker Messick will start for the Guardians here and Messick is 3-0 with a 1.05 ERA and 25 strikeouts this season. This will be Messick’s first career start against the Astros.
Houston Astros Recap
The Houston Astros come into this game looking to add on to their 9-2 win over Cleveland from Monday’s series opener to sit at 9-15 this season. After this series, the Astros will head home for a set against the New York Yankees.
Astros Snap Four-Game Losing Streak
Entering Monday’s opener, Yordan Alvarez has 27 hits with 7 doubles, 10 home runs and 21 RBIs while Christian Walker has 20 hits with 6 doubles, 4 home runs and 16 RBIs on the year. Jose Altuve’s chipped in 25 hits with 6 doubles, 3 home runs and 8 RBIs and Carlos Correa has 19 hits with 5 doubles, a home run and 10 RBIs. Cam Smith also has 19 hits with 5 doubles, 3 home runs and 10 RBIs. Yainer Diaz also has 12 hits with 2 doubles, a home run and 9 RBIs.
Cleveland Guardians Recap
The Cleveland Guardians come into this game looking to bounce back from their loss at the hands of the Astros on Monday to sit at 13-11 this season. After this series, the Guardians will head on the road for a series against the Toronto Blue Jays.
Guardians Have Two-Game Win Streak Snapped
Going into Monday, Chase DeLauter has 16 hits with 5 doubles, 5 home runs and 12 RBIs while Steven Kwan has 20 hits with 3 doubles, a home run and 8 RBIs and Jose Ramirez has 19 hits with 4 doubles, 6 home runs and 12 RBIs this season. Brayan Rocchio has also added 17 hits with 2 doubles, 3 home run and 14 RBIs this season while Angel Martinez has 17 hits with 4 doubles, 2 homers and 9 RBIs and Rhys Hoskins has added 10 hits with 5 doubles, a home run and 5 RBIs.
Houston Astros @ Cleveland Guardians Betting Trends: April 21, 2026
- Probable Starting Pitcher: Parker Messick Record this season: 3-0 ERA: 1.05
- Home Record: 1-0
- Last 5 against Astros: –
Why the Cleveland Guardians will win
- The Guardians have won each of their last nine night games following a loss.
- The Astros have lost eight of their last nine road games.
- The Guardians have covered the run line in each of their last eight night games following a loss.
- The Astros have failed to cover the run line in five of their last six road games against American League opponents following a win.
- The Astros have trailed after 5 innings in seven of their last eight night games against opponents that held a winning record.
- The Astros have lost the first inning in five of their last six road games.
- The Guardians have led after 3 innings in each of their last eight Tuesday night games against American League opponents that held a losing record.
- Probable Starting Pitcher: Ryan Weiss Record this season: 0-2 ERA: 6.75
- Road Record: 0-2
- Last 5 against Guardians: –
Why the Houston Astros will win
- The underdogs have won each of the Astros’ last five games.
- The Guardians have lost each of their last six games against AL West opponents that held a losing record.
- The road team has covered the run line in eight of the last nine games between the Astros and Guardians.
- The Guardians have failed to cover the run line in each of their last five home games against AL West opponents.
- The Astros have led after 5 innings in 12 of their last 13 night games against the Guardians at Progressive Field.
Total Runs Facts
- Each of the Astros’ last seven night games against American League opponents have gone OVER the total runs line.
- Five of the Guardians’ last six games against AL West opponents have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last nine games as underdogs.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the last eight night games between the Astros and Guardians at Progressive Field.
Cleveland Guardians Player Prop Facts
- Jose Ramirez has hit a home run in three of the Guardians’ last four games against the Astros.
- Brayan Rocchio has recorded at least one hit in each of his last 11 appearances with the Guardians as favorites.
- Jose Ramirez ranks 1st in the league in Steals (10) this season.
Houston Astros Player Prop Facts
- Yordan Alvarez has hit a home run in three of the Astros’ last four games.
- Isaac Paredes has recorded at least one hit in each of his last nine appearances against AL opponents.
- Yordan Alvarez ranks 1st in the league in Home Runs (10) this season.
Matchup/League Facts
- The Guardians rank 30th in the league for triples this season (0).
- The Guardians rank 1st in the league for strikeouts this season (233).
- The Astros rank 1st in the league for doubles this season (55).
- The Astros rank 30th in the league for ERA this season (5.93).
Houston Astros vs. Cleveland Guardians Prediction
I’m on the Guardians here. I know Cleveland fell short in Monday’s opener but I think they can bounce back here as Messick is one of the best that the Guardians have in this rotation right now and I haven’t been the biggest fan of the Astros against left-handed pitching. I think this is a nice bounce back situation for the Guardians so give me Cleveland in this one.