Cleveland Guardians vs. Chicago White Sox Prediction 05-24-2023 MLB Picks

Chris RuffoloMay 24, 2023
Cleveland Guardians vs. Chicago White Sox Prediction 05-24-2023 MLB Picks player photo
Credit: USA Today Sports

The Chicago White Sox and the Cleveland Guardians meet in an AL Central matchup in MLB action from Progressive Field on Wednesday. Let’s dive into the odds, starting pitching matchup, history and make a prediction for this game.


Cleveland is listed as a -130 home favorite while the White Sox are +110 road underdogs. The total for this game is set at 8 runs.

Starting Pitching Matchup

Michael Kopech will start for the White Sox and is 2-4 with a 4.83 ERA and 51 strikeouts this season. Cal Quantrill will start for Cleveland and is 2-2 with a 4.06 ERA and 29 strikeouts this season.

Matchup History

Chicago’s 4-2 win over the Guardians on Tuesday snapped Cleveland’s two-game win streak in this head-to-head matchup.


Chicago is 4-13 in their last 17 road games and 5-15 in their last 20 games following a win while the under is 6-0 in their last 6 games overall. Cleveland is 1-4 in their last 5 games overall and 2-5 in their last 7 games against a team with a winning record while the under is 11-2-1 in their last 14 division games.


I’m backing the over here. I don’t trust the pitching matchup of Kopech vs. Quantrill as Kopech’s still up amongst the highest home run totals allowed by a starter this season and Quantrill in my opinion from watching his starts has been average at best. The offenses haven’t been anything to write home about as of late, but I think the pitching matchup produces some runs here.

Chris Ruffolo's Free Pick:Over 8
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Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg