Cleveland Guardians vs. St. Louis Cardinals Prediction 5-26-23 MLB Picks

Chris RuffoloMay 26, 2023
Cleveland Guardians vs. St. Louis Cardinals Prediction 5-26-23 MLB Picks player photo
Credit: USA Today Sports

The St. Louis Cardinals and the Cleveland Guardians meet in interleague action from Progressive Field on Friday night. Let’s dive into the odds, starting pitching matchup, history and make a prediction for this game.


Cleveland is listed as a -120 home favorite while St. Louis is a +100 road underdog. The total for this game is set at 8 runs.

Starting Pitching Matchup

Matthew Liberatore will start for the Cardinals here and is 1-0 with a 3.00 ERA and 7 strikeouts this season. Cleveland will start Shane Bieber here and Bieber is 3-3 with a 3.08 ERA and 47 strikeouts this season.

Matchup History

Cleveland’s 7-2 win over St. Louis back on July 28th, 2021, snapped the Cardinals’ two-game win streak in this head-to-head matchup.


St. Louis is 13-5 in their last 18 games overall and 5-2 in their last 7 road games while the over is 4-0 in their last 4 series-opening games. Cleveland is 2-6 in their last 8 games against a team with a losing record and 1-5 in their last 6 games overall while the under is 9-2-2 in their last 13 series-opening games.


I’m backing the under here. I just can’t trust this Guardians offense to produce much of anything in their recent form, and while the Cardinals have been hitting better, I still don’t expect a whole lot off of Shane Bieber here. I could easily see this ending up as a first to 3 wins kind of game, so give me the under here.

Chris Ruffolo's Free Pick:Under 8
Chris Ruffolo photograph

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg