Cubs vs Astros Prediction 5/22/26 MLB Picks Today

In this article we will formulate a Cubs vs Astros prediction for this MLB game on Friday, May 22nd at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Chicago Cubs Betting Preview

The Chicago Cubs are 29-21 this year after they lost all three against the Brewers by scores of 3-9, 2-5, and 0-5. In game three, Chicago fell behind in the third inning and they never found any offense in the shutout loss. The Cubs recorded two hits and they committed three errors, while they were led by Bregman, who went 1-4 in the game. Cabrera allowed four hits and one earned run over 3.0 innings for the loss, while Maton allowed one earned run in relief. Prior to that series, Chicago lost two out of three against the White Sox and two out of three against the Braves. 

This season, Chicago has a 4.07 ERA with a 1.23 WHIP and a .236 opponent batting average, while they have scored 246 runs with a .242 batting average and a .338 on base percentage. Nico Hoerner has led the Cubs with four home runs and 30 RBIs, while Dansby Swanson has added seven home runs and 27 RBIs. The projected starting pitcher for Chicago is Jameson Taillon, who is 2-3 with a 4.97 ERA and a 1.20 WHIP over 50.2 innings pitched this year. 

Houston Astros Betting Preview

The Houston Astros are 20-31 this season after they lost two out of three against the Twins by scores of 3-6, 2-1, and 1-4. In game three, Houston led 1-0 in the second inning, but they went scoreless over the last seven innings in the loss. The Astros recorded five hits in the game and they were led by Vazquez, who went 1-2 with one RBI. Burrows allowed six hits and four earned runs over 6.0 innings for the loss, while Pearson threw a scoreless inning in relief. Prior to that series, Houston won two out of three against the Rangers, but lost three out of four against the Mariners before that. 

This season, Houston has a 5.34 ERA with a 1.53 WHIP and a .255 opponent batting average, while they have scored 218 runs with a .246 batting average and a .321 on base percentage. Yordan Alvarez has led the Astros with 15 home runs and 31 RBIs, while Christian Walker has added 11 home runs and 31 RBIs. The projected starting pitcher for Houston is Spencer Arrighetti, who is 5-1 with a 1.50 ERA and a 1.19 WHIP over 36.0 innings pitched this season. 

Why the Chicago Cubs will win

Why the Houston Astros will win

Total Runs Facts

Chicago Cubs Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Cubs vs Astros Prediction 

Houston comes into this matchup after losing three of their last four games and they have scored a total of six runs in their last four games. The Astros are 8-17 on the road this year, while the Cubs are 18-8 at home. Chicago has lost nine of their last eleven games and they have allowed 5+ runs in six straight. The Cubs are starting Taillon, who has allowed 8, 1, 2, 3, and 4 earned runs in his last five starts, while Arrighetti has allowed one earned run or fewer in four straight starts. Houston has the better starter, but I don’t trust their bats. Take the Cubs here. 

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