Cubs vs Mariners Prediction 6/21/25 MLB Picks Today

The Seattle Mariners and the Chicago Cubs meet Saturday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs Mariners Prediction.

Starting Pitching Matchup

The Seattle Mariners will trot out Emerson Hancock for the start here, and Hancock is 3-2 with a 4.48 ERA and 45 strikeouts this season. This will be Hancock’s second career start against the Cubs. The Chicago Cubs will send out Cade Horton for the start here, and Horton is 3-1 with a 3.47 ERA and 29 strikeouts this season. This will be Horton’s first career start against the Mariners.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to build on their 9-4 win to start the series on Friday and to improve to 38-36 on the year. After this series, the Mariners will head on the road for a series against the Minnesota Twins.

Mariners Win 5 Of Their Last 7

Jorge Polanco has 52 hits, including 11 home runs and 36 RBIs, while Cal Raleigh has 71 hits with 14 doubles, a team-high 27 home runs, and 60 RBIs. Randy Arozarena has 58 hits with 15 doubles, 8 home runs, 28 RBIs, and 14 stolen bases. Julio Rodriguez also has 75 hits with 3 triples, 10 home runs, 34 RBIs, and 12 stolen bases. Dylan Moore has 8 homers and 9 stolen bases as well this season. Rowdy Tellez has also added 11 home runs and 27 RBIs, while J.P. Crawford has 72 hits with 10 doubles, 6 home runs, and 29 RBIs.

Why the Seattle Mariners will win

Seattle Mariners Player Prop Facts

Chicago Cubs Recap

The Chicago Cubs come into this game looking to bounce back from their series-opening loss at the hands of the Mariners on Friday to slip to 45-30 on the year. After this series, the Cubs will head on the road for a series against the St. Louis Cardinals.

Cubs Drop Back-To-Back Games

Ian Happ has 65 hits with 14 doubles, 8 home runs, and 33 RBIs. Kyle Tucker has 76 hits, including 15 doubles, 4 triples, 13 home runs, and 43 RBIs, while Seiya Suzuki also has 72 hits with 18 doubles and 18 home runs and 61 RBIs of his own. Miguel Amaya added 9 doubles and 25 RBIs, and Pete Crow-Armstrong also has contributed 77 hits, 16 doubles, 3 triples, 20 home runs, and 60 RBIs as well this season. Dansby Swanson has added 14 home runs and 39 RBIs, while also having the unfortunate distinction of leading the Cubs with 84 strikeouts so far this season. Crow-Armstrong also has a team-high 23 stolen bases, while Nico Hoerner has 14 stolen bases this season. Tucker’s also added 18 stolen bases while Michael Busch has also chipped in 13 doubles, 3 triples, 11 home runs, and 39 RBIs this season.

Why the Chicago Cubs will win

Chicago Cubs Player Prop Facts

Total Runs Facts

Cubs vs Mariners Prediction

I’m on the over here. Normally, when you see a sky-high total like this at Wrigley Field, it’s for a good reason, as this is one of the most weather-affected ballparks in Major League baseball. Both starters have been somewhat questionable, and both offenses have been putting up some runs as of late. And I think we have another high-scoring game here. Give me the over.

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