Cubs vs Padres Prediction 4/4/25 MLB Picks Today

The San Diego Padres and the Chicago Cubs meet Friday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cubs vs Padres Prediction.

Starting Pitching Matchup

The San Diego Padres will send out Randy Vasquez for the start here and Vasquez is 0-0 with a 0.00 ERA and 3 strikeouts this season. This will be Vasquez’s second career start against the Cubs. The Chicago Cubs will start Shota Imanaga here and Imanaga is 1-0 with a 0.82 ERA and 6 strikeouts this season. This will be Imanaga’s second career start against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game with a 7-0 record after a second straight series sweep to start the year, picking up a 5-2 win over the Guardians last time out. After this series, the Padres will head back west for a series against the Athletics.

Padres Looking To Stay Unbeaten

Fernando Tatis Jr. leads the Padres with 11 hits and a .423 batting average while Manny Machado and Jackson Merrill each have 10 hits, with Machado logging 3 doubles while Merrill has a team-high 2 home runs and 8 RBIs. Gavin Sheets and Xander Bogaerts each have a pair of doubles as well this season with Sheets logging 5 RBIs as well this season.

Why the San Diego Padres will win

San Diego Padres Player Prop Facts

Chicago Cubs Recap

The Chicago Cubs will be out to add on to their series sweep over the Athletics thanks to a 10-2 win in Wednesday’s series finale to improve to 5-4 on the year. After this series, the Cubs will welcome the Texas Rangers to town.

Cubs Trying To Hand Padres First Loss To Extend Win Streak

Kyle Tucker leads the Cubs with 12 hits including team-highs of 5 doubles, 4 home runs and 11 RBIs while Seiya Suzuki also has 11 hits with a pair of doubles and 4 home runs and 11 RBIs of his own. Miguel Amaya’s added 4 doubles and 7 RBIs and Dansby Swanson and Pete Crow-Armstrong have each contributed 3 doubles as well this season with Swanson belting a pair of home runs and 6 RBIs. Suzuki also has the unfortunate distinction of leading the Cubs with 17 strikeouts so far this season.

Why the Chicago Cubs will win

Chicago Cubs Player Prop Facts

Total Runs Facts

Cubs vs Padres Prediction

I’m on the Cubs here. I think that while the Padres’ start to the season is something to be excited about if you’re a Padres fan, the fact is that you’re still relying on Randy Vasquez to be a contributing member of this rotation. In reality, he’s a #5 starter or long relief arm at best. Shota Imanaga is one of the best pitchers in the national league in just his second season in the majors, and I think that Imanaga delivers another gem and gets the win in this one. Give me Chicago here to hand the Padres their first L of the season.

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