Cubs vs White Sox Prediction 5/16/25 MLB Picks Today

The Chicago White Sox and Chicago Cubs meet Friday in MLB action at Wrigley Field. Here’s a Cubs vs White Sox Prediction. This article will include a Cubs vs White Sox Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 14-30 on the year and play the Mariners, Rangers, and Mets next. The Chicago White Sox are batting .214 on the season, have a .289 OBP, and a .324 slugging percentage. The Chicago White Sox pitching staff has a 4.04 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 40 hits and 11 RBI, while Miguel Vargas and Andrew Vaughn have combined for 64 hits and 34 RBI.

Shane Smith gets the ball for the Chicago White Sox, and he is 1-2 with a 2.08 ERA and 38 strikeouts this season. This will be Smith’s first career game against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 25-19 on the year and play the Marlins, Reds, and Rockies next. The Chicago Cubs are batting .250 on the season, have a .327 OBP, and a .436 slugging percentage. The Chicago Cubs pitching staff has a 4.02 ERA and a 1.30 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 45 hits and 30 RBI, while Kyle Tucker and Ian Happ have combined for 88 hits and 52 RBI.

Cade Horton gets the ball for the Chicago Cubs, and he is 1-0 with a 6.75 ERA and 5 strikeouts this season. This will be Horton’s first career game against the Chicago White Sox.

Why the Chicago Cubs will win

Why the Chicago White Sox will win

Chicago Cubs Player Prop Facts

Chicago White Sox Player Prop Facts

Cubs vs White Sox Prediction

The White Sox have won four of their last six games, but they’re not a team I’m eager to back. Those few wins don’t move the needle. The White Sox were the worst team in baseball the last two years and are 16 games below a .500 record this season. A $100 bettor is down more than $2,400 this season, backing the White Sox all season. There’s zero betting value with the White Sox, and it’s just that simple. Horton wasn’t good in his season debut, allowing four hits and three runs in four innings against the Mets. Who cares. The White Sox stink. Give me the Cubs and the RL for max betting value.

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