Cubs vs White Sox Prediction 7/25/25 MLB Picks Today

In this article, we will formulate a Cubs vs White Sox Prediction for this MLB game on Friday, July 25th at the Rate Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview

The Chicago White Sox have a 37-66 record this season and are sitting on the last place of the AL Central. The White Sox have a 21-29 home record and are 45-53 in over/under. They are coming off a 11-9 road victory over the Rays, and are 5-1 in their last 6 games. Over is 5-2 in their last 7 games and are playing the Phillies and the Angels next.

The White Sox have a .224 batting average this season, .298 OBP and .354 Slugging percentage. Chicago’s pitching staff has a 4.08 ERA and 1.38 WHIP. Lenyn Sosa leads the White Sox with 81 hits, while Luis Robert Jr. leads the team in RBI with 41. Chase Meidroth is the team’s best hitter with a .250 batting average, while Miguel Vargas adds a team-high 12 home runs.

Adrian Houser (R) is the projected starter for the White Sox, and he has a 5-2 record, 1.89 ERA and 1.23 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 60-42 record this season and are sitting on the second place of the NL Central. The Cubs have a 27-23 road record and are 50-43 in over/under. They are coming off a 4-8 home defeat by the Royals, and are 1-3 in their last 4 games. Over is 3-1 in their last 4 games, and are playing the Orioles and the Brewers next.

The Cubs have a .256 batting average this season, .324 OBP and .446 Slugging percentage. Chicago’s pitching staff has a 3.86 ERA and 1.22 WHIP. Nico Hoerner leads the Cubs with 107 hits, and he is the team’s best hitter with a .286 batting average. Seiya Suzuki leads the team in RBI, with 81, while Pete Crow-Armstrong adds a team-high 27 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 7-3 record, 2.40 ERA and 0.92 WHIP.

Why the Chicago White Sox will win

Why the Chicago Cubs will win

Total Runs Facts

Matchup/League Facts

Chicago Cubs vs Chicago White Sox 7/25/25 MLB Pick & Prediction | MLB Betting Tips

Cubs vs White Sox Prediction

The Cubs have won their last 8 meetings against the White Sox, and have won their last three visits in Rate Field. Over is 5-1-1 in their last 7 meetings.

In this Cubs vs White Sox Prediction, the Cubs are coming as -180 road favorites. The Cubs are rightfully favored, as they have a superior overall record, and have been above average on the road. Houser has been lights out for the White Sox, as he boasts an insane 0.69 home ERA. Imanaga has also been better on the road, with a 1.33 road ERA, and both pitchers have been in excellent form lately, with a combined 3.43 ERA in their last five starts. I like both pitchers to suppress the opposing offenses, so take the under 4.5 runs in the first 5 innings of this game.

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