The San Francisco Giants and Arizona Diamondbacks meet Wednesday in MLB action at Chase Field. Here’s a Diamondbacks vs Giants Prediction. This article will include a Diamondbacks vs Giants Pick.
San Francisco Giants Betting Preview
The San Francisco Giants are 75-76 on the year and play the Dodgers, Cardinals, and Rockies next. The San Francisco Giants are batting .237 on the season, have a .312 OBP, and a .388 slugging percentage. The San Francisco Giants pitching staff has a 3.87 ERA and a 1.31 WHIP. Heliot Ramos leads the San Francisco Giants with 149 hits and 61 RBI, while Jung Hoo Lee and Willy Adames have combined for 265 hits and 134 RBI.
Justin Verlander gets the ball for the San Francisco Giants, and he is 3-10 with a 3.94 ERA and 124 strikeouts this season. Verlander is 5-3 with a 3.13 ERA and 63 strikeouts in his career against the Arizona Diamondbacks.
Arizona Diamondbacks Betting Preview
The Arizona Diamondbacks are 77-75 on the year and play the Phillies, Dodgers, and Padres next. The Arizona Diamondbacks are batting .252 on the season, have a .325 OBP, and a .436 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.45 ERA and a 1.31 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 161 hits and 97 RBI while Corbin Carroll and Lourdes Gurriel Jr. have combined for 262 hits and 157 RBI.
Brandon Pfaadt gets the ball for the Arizona Diamondbacks, and he is 13-8 with a 5.31 ERA and 131 strikeouts this season. Pfaadt is 0-4 with a 5.11 ERA and 27 strikeouts in his career against the San Francisco Giants.
San Francisco Giants @ Arizona Diamondbacks Betting Trends: September 17, 2025
- Probable Starting Pitcher: Brandon Pfaadt Record this season: 13-8 ERA: 5.31
- Home Record: 9-3
- Last 5 against Giants: 0-4
Why the Arizona Diamondbacks will win
- The Giants have lost each of their last seven day games against NL West opponents following a loss.
- The Diamondbacks have won seven of their last eight home games against National League opponents.
- The Giants have failed to cover the run line each of their last four day games against NL West opponents that held a winning record.
- The Diamondbacks have covered the run line in five of their last six games.
- The Diamondbacks have led after 5 innings in each of their last six home games against NL West opponents that held a losing record.
- The Diamondbacks have led after 3 innings in seven of their last eight home day games.
- The Diamondbacks have won the first inning in 12 of their last 13 home games against National League opponents.
- Probable Starting Pitcher: Justin Verlander Record this season: 3-10 ERA: 3.94
- Road Record: 1-4
- Last 5 against Diamondbacks: 2-2
Why the San Francisco Giants will win
- The Diamondbacks have lost eight of their last nine day games against National League opponents that held a losing record.
- The underdogs have won seven of the Diamondbacks’ last 10 games at Chase Field.
- The Diamondbacks have failed to cover the run line in eight of their last nine day games against National League opponents that held a losing record.
- The Giants have covered the run line in each of their last five games following a road loss.
- The Giants have won the first inning in five of their last six games against opponents that held a winning record.
- The Giants have led after 3 innings in five of their last six road games against NL West opponents.
Total Runs Facts
- Five of the Diamondbacks’ last six games as favorites against the Giants have gone OVER the total runs line.
- Five of the Giants’ last six day games against National League opponents have gone UNDER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last 13 home games against National League opponents.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last four games at Chase Field.
Arizona Diamondbacks Player Prop Facts
- Brandon Pfaadt has recorded five or more strikeouts in five of his last six appearances in day games.
- Geraldo Perdomo has recorded a Double in three of the Diamondbacks’ last four home games against NL West opponents.
- James McCann has hit a home run in three of his last four appearances with his team as a favorite against the Giants.
- Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 17 games as favorites.
- Brandon Pfaadt has recorded a win in four of his last five home appearances against NL West opponents.
- Geraldo Perdomo ranks 6th amongst qualified players for On Base Percentage (.393) this season.
San Francisco Giants Player Prop Facts
- Wilmer Flores has hit a home run in two of his last three road appearances against NL West opponents.
- Heliot Ramos has recorded at least one hit in each of the Giants’ last 17 Wednesday games.
- Justin Verlander has recorded six or more strikeouts in six of his last seven appearances in day games against NL teams that held a winning record.
Matchup/League Facts
- The Diamondbacks rank 1st in the league for triples this season (36).
- The Diamondbacks rank 3rd in the league for RBIs this season (736).
- The Giants rank 1st in the league for home runs allowed this season (129).
- The Giants rank 29th in the league for steals this season (65).
Diamondbacks vs Giants Prediction
The Diamondbacks are playing the better ball right now, but I’m still rolling with the Giants in this spot. Pfaadt hasn’t been good this season with a 5.31 ERA and 1.40 WHIP, and he’s allowed 31 hits and 16 runs in his last 17.2 innings. Verlander saved his best for last, as he’s allowed 10 hits and 1 runs in his last 18 innings. Verlander has allowed 2 or fewer runs in his last 4 starts. Big game for both teams, but give me the Giants behind their Hall of Fame who has found his form all of a sudden.