Diamondbacks vs Giants Prediction 9/17/25 MLB Picks Today

The San Francisco Giants and Arizona Diamondbacks meet Wednesday in MLB action at Chase Field. Here’s a Diamondbacks vs Giants Prediction. This article will include a Diamondbacks vs Giants Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 75-76 on the year and play the Dodgers, Cardinals, and Rockies next. The San Francisco Giants are batting .237 on the season, have a .312 OBP, and a .388 slugging percentage. The San Francisco Giants pitching staff has a 3.87 ERA and a 1.31 WHIP. Heliot Ramos leads the San Francisco Giants with 149 hits and 61 RBI, while Jung Hoo Lee and Willy Adames have combined for 265 hits and 134 RBI.

Justin Verlander gets the ball for the San Francisco Giants, and he is 3-10 with a 3.94 ERA and 124 strikeouts this season. Verlander is 5-3 with a 3.13 ERA and 63 strikeouts in his career against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 77-75 on the year and play the Phillies, Dodgers, and Padres next. The Arizona Diamondbacks are batting .252 on the season, have a .325 OBP, and a .436 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.45 ERA and a 1.31 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 161 hits and 97 RBI while Corbin Carroll and Lourdes Gurriel Jr. have combined for 262 hits and 157 RBI.

Brandon Pfaadt gets the ball for the Arizona Diamondbacks, and he is 13-8 with a 5.31 ERA and 131 strikeouts this season. Pfaadt is 0-4 with a 5.11 ERA and 27 strikeouts in his career against the San Francisco Giants.

San Francisco Giants @ Arizona Diamondbacks Betting Trends: September 17, 2025

 

Why the Arizona Diamondbacks will win

 

Why the San Francisco Giants will win

Total Runs Facts

Arizona Diamondbacks Player Prop Facts

San Francisco Giants Player Prop Facts

Matchup/League Facts

Diamondbacks vs Giants Prediction

The Diamondbacks are playing the better ball right now, but I’m still rolling with the Giants in this spot. Pfaadt hasn’t been good this season with a 5.31 ERA and 1.40 WHIP, and he’s allowed 31 hits and 16 runs in his last 17.2 innings. Verlander saved his best for last, as he’s allowed 10 hits and 1 runs in his last 18 innings. Verlander has allowed 2 or fewer runs in his last 4 starts. Big game for both teams, but give me the Giants behind their Hall of Fame who has found his form all of a sudden.

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