Dodgers vs Giants Prediction 9/21/25 MLB Picks Today

The San Francisco Giants and Los Angeles Dodgers meet Sunday in MLB action at Dodger Stadium. Here’s a Dodgers vs Giants Prediction. This article will include a Dodgers vs Giants Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 76-79 on the year and play the Cardinals and Rockies next. The San Francisco Giants are batting .235 on the season, have a .311 OBP, and a .385 slugging percentage. The San Francisco Giants pitching staff has a 3.87 ERA and a 1.30 WHIP. Heliot Ramos leads the San Francisco Giants with 152 hits and 62 RBI, while Jung Hoo Lee and Willy Adames have combined for 269 hits and 134 RBI.

Trevor McDonald gets the ball for the San Francisco Giants, and he is 0-0 with a 9.00 ERA and 1 strikeout this season. This will be McDonald’s first career game against the Los Angeles Dodgers.

Los Angeles Dodgers Betting Preview

The Los Angeles Dodgers are 88-67 on the year and play the Diamondbacks and Mariners next. The Los Angeles Dodgers are batting .254 on the season, have a .330 OBP, and a .441 slugging percentage. The Los Angeles Dodgers pitching staff has a 4.03 ERA and a 1.27 WHIP. Shohei Ohtani leads the Los Angeles Dodgers with 166 hits and 99 RBI while Freddie Freeman and Andy Pages have combined for 311 hits and 167 RBI.

Emmet Sheehan gets the ball for the Los Angeles Dodgers, and he is 6-3 with a 3.17 ERA and 76 strikeouts this season. Sheehan is 1-0 with a 1.20 ERA and 15 strikeouts in his career against the San Francisco Giants.

San Francisco Giants @ Los Angeles Dodgers Betting Trends: September 21, 2025

Why the Los Angeles Dodgers will win

Why the San Francisco Giants will win

Total Runs Facts

Los Angeles Dodgers Player Prop Facts

San Francisco Giants Player Prop Facts

Matchup/League Facts

Dodgers vs Giants Prediction

The Giants are watching their season fall apart, with losses in 7 of their last 8 games. It’s hard to take the Giants seriously in their current form. McDonald also has just 5 career MLB innings under his belt, so the small sample size makes him hard to back. The Dodgers are heating up and Sheehan has allowed 11 hits and 4 runs in his last 24.1 innings. In 36.2 home innings, Sheehan has a 2.21 ERA and .191 allowed batting average. The Dodgers put their hated rival out of their misery. Of course, I’ll lay the RL to shave down the juice.

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