Major League Baseball presents FanDuel baseball fans with an interleague matchup featuring the Cleveland Guardians and the Arizona Diamondbacks. Let’s take a look at this MLB game from a DFS perspective.
Before we dive into the Cleveland Guardians vs. Arizona Diamondbacks game let’s review the rules for the FanDuel single game showdown contest.
FanDuel Single Game Contest Rules
Here are the FanDuel single game contest rules. You have $60,000 to utilize on five players from either team. However, one of those players will be designated as your team MVP. The MVP accumulates 1.5x times the standard FanDuel fantasy points value. Additionally, the MVP is 1.5 times the standard cost of the flex position.
The remaining five players in your lineup will be flex plays. The five flex positions will receive the standard FanDuel points value. Having stated that, it is highly important for you to identify the correct player for your MVP position if you hope to win a large field GPP (guaranteed prize pool) FanDuel single game contest.
If you have additional questions regarding the rules for the single game contest, I highly recommend that you check out the FanDuel website for more details.
*It should be noted that FanDuel does not utilize the pitcher position in single game MLB contests. Having stated that, only batters are available for single game MLB lineups on the FanDuel platform.
Here are my FanDuel picks for this afternoon’s Guardians vs. Diamondbacks matchup.
FanDuel MLB DFS Picks
MVP-Jose Ramirez, Third Baseman, Cleveland Guardians $13,400
On Wednesday afternoon, Major League Baseball presents the final game of a three-game interleague series featuring the Cleveland Guardians and the Arizona Diamondbacks.
How are these two teams playing entering today’s MLB game? The Cleveland Guardians arrive at the third game of this three-game series with the Arizona Diamondbacks playing below average baseball. The Guardians have lost four of the team’s last five games played in the 2025 MLB regular season, including a 2-0 shutout loss to the Atlanta Braves last week.
Similar to the Cleveland Guardians, the Arizona Diamondbacks arrive at today’s interleague game playing subpar baseball. More specifically, the Diamondbacks have lost four of the team’s last five games played this season, including a 6-5 loss to the Colorado Rockies.
Now that we have identified how both of these teams are currently playing let’s shift our focus to today’s contest. Veteran third baseman Jose Ramirez has been a solid contributor for the Cleveland Guardians this season. With that said, how has Ramirez performed from a statistical standpoint? Let’s examine Ramirez’s relevant game data from the 2025 MLB regular season to answer that question.
In the 122 games that Jose Ramirez has played for the Cleveland Guardians in the 2025 MLB regular season, Ramirez has compiled a robust .291 batting average, 26 home runs, 51 walks, 66 RBIs (runs batted in), 81 runs scored, a .365 OBP (On-Base Percentage) and a .884 OPS (On-Base Plus Slugging) which ranks 26th in MLB.
What did we learn from the data just presented? Clearly, Jose Ramirez can post a high number of DFS points on any given night. Having stated that, I fully expect that trend to continue in this afternoon’s matchup with the Arizona Diamondbacks.
In my view, Jose Ramirez is the most likely player to accumulate the most FanDuel points in this MLB game. For that specific reason, I am backing Cleveland Guardians third baseman Jose Ramirez at the MVP position for this one game MLB DFS slate.
Flex plays I like in this MLB regular season game (FanDuel price noted): Corbin Carroll, Outfielder (Arizona Diamondbacks) $13,800: Geraldo Perdomo, Shortstop (Arizona Diamondbacks) $12,000: Steven Kwan, Outfielder (Cleveland Guardians) $8,600.