Giants vs Brewers Prediction 4/21/25 MLB Picks Today

In this article, we will formulate a Giants vs Brewers prediction for this MLB game on Monday, April 21st at Oracle Park in San Francisco, California. Let’s take a look at the prediction for this MLB matchup. 

San Francisco Giants Betting Preview

The San Francisco Giants are 14-8 this season after they lost two out of three against the Angels by scores of 0-2, 3-2, and 4-5. In that game three loss, San Francisco led 4-1 in the eighth inning, but they allowed four runs in the bottom of the ninth for the loss. The Giants recorded eight hits in the game, and they were led by Huff and Adames, who both had two RBIs in the loss. San Francisco started Verlander, who allowed two hits and one earned run over 6.0 innings, while Walker allowed three hits and four earned runs in the ninth for the loss. 

Prior to that series, the Giants split four games with the Phillies and won two out of three against the Yankees. San Francisco has lost four of their last six games, and they are currently third in the NL West standings. The San Francisco pitching staff has a 3.53 ERA with a 1.22 WHIP, and a .223 opponent batting average, while the offense has scored 111 runs with a .224 batting average and a .305 on-base percentage this season. Wilmer Flores has led San Francisco with six home runs and 23 RBIs, while Matt Chapman has added four home runs and 14 RBIs this year. The projected starting pitcher for San Francisco is Robbie Ray, who is 3-0 with a 4.19 ERA and a 1.55 WHIP over 19.1 innings pitched this season. 

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 12-10 this year after they won two out of three against the Athletics by scores of 5-3, 1-3, and 14-1. In that game three win, the Brewers scored the first eight runs in the game, and they were able to cruise to the win in the final five innings. Milwaukee recorded 16 hits in the game, and they were led by Hoskins, who went 3-5 with one home run and four RBIs in the win. Milwaukee started Henderson, who allowed three hits and one earned run over 6.0 innings in the win, while Alexander pitched the final three innings for the save. 

Prior to that series, the Brewers won two out of three against the Tigers, but did lose two out of three against the Diamondbacks before that. Milwaukee has won four of its last five games, and they are currently second in the NL Central standings. The Milwaukee pitching staff has a 4.16 ERA with a 1.28 WHIP and a .231 opponent batting average, while the offense has scored 112 runs with a .240 batting average and a .312 on-base percentage this season. Jackson Chourio has led Milwaukee with five home runs and 19 RBIs, while Christian Yelich has added four home runs and 15 RBIs this year. The projected starting pitcher for Milwaukee is Quinn Priester, who is 1-0 with a 0.90 ERA and a 1.20 WHIP over 10.0 innings pitched this year. 

Why the Giants will beat the Brewers

• The Brewers have lost each of their last 10 Monday road games.
• The Giants have won seven of their last eight night games against National League opponents following a road loss.
• The Brewers have failed to cover the run line in each of their last eight Monday road games against National League opponents.
• The Giants have covered the run line in seven of their last eight night games against National League opponents following a road loss.
• The Giants have led after 3 innings in six of their last seven night games against opponents that held a winning record.
• The Giants have led after 5 innings in five of their last six night games against opponents that held a winning record.

Total Runs Facts

• Each of the Giants’ last five games against National League opponents have gone OVER the total runs line.
• Six of the Brewers’ last eight road games against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Brewers’ last eight night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last five games against NL Central opponents.

San Francisco Giants Player Prop Facts

• Willy Adames has hit at least one home run in three of his last four appearances against former teams.
• Matt Chapman has recorded at least one RBI in five of his last six appearances with his team as a home favorite against the Brewers.
• Mike Yastrzemski has recorded a Double in four of the Giants’ last five night games against opponents that held a winning record.
• Matt Chapman has recorded two hits in each of the Giants’ last four games against opponents that held a winning record.
• Heliot Ramos has scored at least one run in each of his last five appearances against NL opponents that held a winning record.
• Heliot Ramos has recorded at least one Single in eight of the Giants’ last nine night games against NL opponents that held a winning record.

Milwaukee Brewers Player Prop Facts

• Rhys Hoskins has hit a home run in each of the Brewers’ last two games against opponents that held a winning record.
• William Contreras has recorded at least one RBI in each of his last seven road appearances against NL West opponents.
• Brice Turang has recorded at least one hit in each of the Brewers’ last 12 night games.
• Brice Turang has scored at least one run in each of the Brewers’ last six road games against opponents that held a winning record.
• Brice Turang has recorded at least one Single in each of the Brewers’ last eight games as underdogs against NL West opponents.

Matchup/League Facts

• The Giants rank T4th in the league for doubles this season (44).
• The Giants rank 5th in the league for RBIs this season (106).
• The Brewers rank 1st in the league for steals this season (33).
• The Brewers rank T27th in the league for home runs allowed this season (30).

Giants vs Brewers Prediction 

Milwaukee comes into this matchup after winning four of their last five games, and they have scored at least five runs in all four of those wins, but they are just 3-6 on the road. San Francisco is 4-2 at home, and they will be looking to bounce back after a very disappointing series against the Angels. The Giants will be going with Ray on the mound, who has allowed one earned run in two of his last three starts. Milwaukee is starting Priester, who has allowed one earned run in 10.0 innings so far this year. I think Priester has overachieved to start this season, and I like the Giants to get the win here.