The St. Louis Cardinals and San Francisco Giants meet Wednesday in MLB action at Oracle Park. Here’s a Giants vs Cardinals Prediction. This article will include a Giants vs Cardinals Pick.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 78-80 on the year and play the Cubs next. The St. Louis Cardinals are batting .246 on the season, have a .316 OBP, and a .381 slugging percentage. The St. Louis Cardinals pitching staff has a 4.24 ERA and a 1.32 WHIP. Alec Burleson leads the St. Louis Cardinals with 143 hits and 69 RBI, while Brendan Donovan and Willson Contreras have combined for 257 hits and 129 RBI.
Sonny Gray gets the ball for the St. Louis Cardinals, and he is 14-8 with a 4.33 ERA and 194 strikeouts this season. Gray is 4-1 with a 3.18 ERA and 44 strikeouts in his career against the San Francisco Giants.
San Francisco Giants Betting Preview
The San Francisco Giants are 77-81 on the year and play the Rockies next. The San Francisco Giants are batting .235 on the season, have a .311 OBP, and a .384 slugging percentage. The San Francisco Giants pitching staff has a 3.88 ERA and a 1.31 WHIP. Heliot Ramos leads the San Francisco Giants with 156 hits and 66 RBI while Jung Hoo Lee and Willy Adames have combined for 272 hits and 137 RBI.
JT Brubaker gets the ball for the San Francisco Giants, and he is 0-0 with a 3.65 ERA and 18 strikeouts this season. Brubaker is 0-6 with a 6.20 ERA and 33 strikeouts in his career against the St. Louis Cardinals.
St. Louis Cardinals @ San Francisco Giants Betting Trends: September 24, 2025
- Probable Starting Pitcher: JT Brubaker Record this season: 0-0 ERA: 3.65
- Home Record: 0-0
- Last 5 against Cardinals: 0-3
Why the San Francisco Giants will win
- The Cardinals have lost each of their last eight Wednesday games against National League opponents that held a losing record.
- The Giants have won nine of their last 10 Wednesday night games against NL Central opponents that held a losing record.
- The Cardinals have failed to cover the run line each of their last eight Wednesday games against National League opponents that held a losing record.
- The Giants have covered the run line in each of their last six Wednesday games against the Cardinals.
- The Giants have won the first inning in four of their last five night games at Oracle Park.
- The Cardinals have trailed after 3 innings in seven of their last eight road games against NL West opponents that held a losing record.
- The Giants have led after 5 innings in five of their last six night games against NL Central opponents.
- Probable Starting Pitcher: Sonny Gray Record this season: 14-8 ERA: 4.33
- Road Record: 4-3
- Last 5 against Giants: 2-1
Why the St. Louis Cardinals will win
- The Giants have lost each of their last eight games as favorites against National League opponents following a home loss.
- The Cardinals have won each of their last four games as underdogs against the Giants.
- The Giants have failed to cover the run line in each of their last 12 games as favorites against National League opponents following a home loss.
- The Cardinals have covered the run line in each of their last nine games as underdogs against the Giants.
- The Cardinals have led after 5 innings in four of their last five games.
- The Cardinals have won the first inning in three of their last four night games at Oracle Park.
- The Cardinals have led after 3 innings in each of their last five Wednesday night games against NL West opponents that held a losing record.
Total Runs Facts
- Nine of the Giants’ last 10 home games after playing the previous day have gone OVER the total runs line.
- Five of the Cardinals’ last six road games against National League opponents have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Giants’ last 10 night games.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last four night games at Oracle Park.
San Francisco Giants Player Prop Facts
- Heliot Ramos has hit a home run in three of the Giants’ last four home games against NL Central opponents.
- Matt Chapman has recorded a Double in three of the Giants’ last four night games against opponents that held a losing record.
- Jung Hoo Lee has recorded at least one hit in each of his last 11 appearances in night games against teams that held a losing record.
- Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.370) this season.
St. Louis Cardinals Player Prop Facts
- Brendan Donovan has recorded at least one Double in four of his last five appearances in night games against NL West teams that held a losing record.
- Sonny Gray has recorded six or more strikeouts in each of his last seven appearances in night games.
- Willson Contreras has hit a home run in three of his last four road appearances against opponents that held a losing record.
- Masyn Winn has recorded at least one hit in each of his last 13 road appearances against NL West opponents that held a losing record.
- Sonny Gray ranks T6th in the league for Wins (14) this season.
Matchup/League Facts
- The Giants rank 1st in the league for home runs allowed this season (139).
- The Giants rank 29th in the league for steals this season (68).
- The Cardinals rank 30th in the league for triples this season (8).
- The Cardinals rank 29th in the league for strikeouts this season (1176).
Giants vs Cardinals Prediction
Gray has been up and down this season and hasn’t had a great September, but we know what he’s capable of when he’s right, and he’s had his moments at times this season. The Giants continue to free fall and don’t feel like a team that’s excited to make a playoff push. Brubaker hasn’t been a difference maker this season, and he’s been owned by the Cardinals in his career. Current Cardinals are batting .256 with a .293 on base percentage and 3 homers in 39 at bats against Brubaker. The Cardinals seem more excited to get to the ballpark this week. Give me the Cardinals for a fourth straight victory.