Giants vs Cardinals Prediction 9/6/25 MLB Picks Today

In this article, we will formulate a Giants vs Cardinals Prediction for this MLB game on Saturday, September 6th at the Busch Stadium in the second game of this series, with the Giants having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 70-72 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 39-34 home record and are 72-62 in over/under. They are coming off a 2-8 home defeat by the Giants, that ended their two-game winning streak. Over is 8-5-1 in their last 14 games and are playing the Brewers and the Mariners next.

The Cardinals have a .246 batting average this season, .314 OBP and .383 Slugging percentage. Saint Louis’ pitching staff has a 4.30 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 123 hits, and he is the team’s best hitter with a .286 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 6-13 record, 5.38 ERA and 1.44 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 72-69 record this season and are sitting on the third place of the NL West. They have a 37-35 road record and are 67-68 in over/under. They are coming off an 8-2 road victory over the Cardinals, and are 11-1 in their last 12 games. Over is 6-1 in their last 7 games and are playing the Dodgers and the Diamondbacks next.

The Giants have a .239 batting average this season, .315 OBP and .392 Slugging percentage. San Francisco’s pitching staff has a 3.76 ERA and 1.29 WHIP.  Heliot Ramos leads the Giants with 145 hits and is the team’s best hitter, with a .269 batting average. Willy Adames leads the team in RBI with 78, adding a team-high 27 home runs.

Justin Verlander (R) is the projected starting pitcher for the Giants, and he has a 3-10 record, 4.29 ERA and 1.43 WHIP.

Why the St. Louis Cardinals will win

Why the San Francisco Giants will win

Total Runs Facts

Matchup/League Facts

Giants vs Cardinals Prediction

The Cardinals are 5-2 in their last 7 head-to-head meetings against the Giants, and are 3-1 in their last 4 meetings in Saint Louis. Over is 8-1 in their last 9 meetings.

In this Giants vs Cardinals Prediction, the Giants are coming as -130 road favorites. I am not interested in backing Verlander as a road favorite, but Pallante has not been better. Both pitchers have a combined 9.67 ERA, with Pallante coming into this matchup in terrible form, having lost his last 5 starts, with a 9.82 ERA in that span. Both pitchers’ home/away splits are even worse, with a combined 11.01 ERA and both teams are better against righties, averaging 9.3 runs per game against right-handed pitching. They are 14-6-1 to the over in their last 21 games combined, and yesterday’s game had 10 total runs. Take the over 8.5 runs in this one.

Exit mobile version