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Giants vs Reds Prediction 4/7/25 MLB Picks Today

Cincinnati Reds (3-7) vs. San Francisco Giants (8-1)
April 7, 2025 9:45 pm EDT
The Line: San Francisco Giants -142 / Cincinnati Reds 120; Over/Under: 6.5
(Get latest betting odds)

In this article we will formulate a Giants vs Reds prediction for this MLB game on Monday, April 7th at Oracle Park in San Francisco, California. Let’s take a look at the prediction for this MLB matchup. 

San Francisco Giants Betting Preview

The San Francisco Giants are 8-1 this year after they won all three games against the Mariners by scores of 10-9, 4-1, and 5-4. In that game three win, the Giants trailed 2-0 early in the game, but ended up blowing a 4-3 lead in the ninth, before winning in the bottom half of the inning. The Giants recorded seven hits and committed one error in the game, while they were led by Yastrzemski, who went 1-3 with one home run and three RBIs in the win. San Francisco started Hicks, who allowed six hits and three earned runs over 5.1 innings, while Doval blew the save in the ninth, but did get the win. 

Prior to that series, the Giants swept the Astros in three games and won two out of three against the Reds. The San Francisco pitching staff has a 2.85 ERA with a 1.24 WHIP and a .233 opponent batting average, while the offense has scored 49 runs with a .238 batting average and a .309 on base percentage this season. Wilmer Flores has led San Francisco with four home runs and 12 RBIs, while Heliot Ramos has added three home runs and nine RBIs this year. The projected starting pitcher for San Francisco is Logan Webb, who is 1-0 with a 3.00 ERA and a 1.17 WHIP over 12.0 innings pitched this season. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 3-7 this season after they lost three out of four against the Brewers by scores of 0-1, 2-3, 11-7, and 2-8. In game four of that series, the Reds allowed the first seven runs in the game, but did score one in the fifth and one in the eighth to avoid the shutout. Cincinnati recorded five hits and they committed one error in the game, while they were led by Friedl and Steer, who both had one RBI in the loss. The Reds started Spiers, who allowed five hits and four earned runs over 3.1 innings, while Moll allowed two hits and three earned runs over just 0.2 relief innings. 

Prior to that series, the Reds lost two out of three against the Rangers and two out of three against the Giants. The Cincinnati pitching staff has a 3.41 ERA with a 1.02 WHIP and a .201 opponent batting average, while their offense has scored 39 runs with a .210 batting average and a .269 on base percentage this season. Elly De La Cruz has led Cincinnati with two home runs and 10 RBIs, while Matt McLain has added three home runs and five RBIs so far this year. The projected starting pitcher for Cincinnati is Hunter Greene, who is 0-1 with a 2.25 ERA and a 0.67 WHIP over 12.0 innings pitched this season. 

Why the Giants will beat the Reds

  • The Giants have won each of their last seven games.
  • The Reds have lost five of their last six games.
  • The Giants have covered the run line in each of their last nine Monday games.
  • The Reds have failed to cover the run line in each of their last four games against NL West opponents.
  • The Reds have lost the first inning in three of their last four night games against opponents that held a winning record.
  • The Giants have led after 5 innings in each of their last seven games.
  • The Giants have led after 3 innings in five of their last six games as home favorites against NL Central opponents.

Total Runs Facts

  • Eleven of the Reds’ last 13 road games against National League opponents have gone UNDER the total runs line.
  • Five of the Giants’ last six games as favorites against National League opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the Reds’ last 13 road games against National League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Giants’ last six night games.

San Francisco Giants Player Prop Facts

  • Jung Hoo Lee has recorded at least one hit in each of his last 11 appearances after playing the previous day.
  • Jung Hoo Lee has scored at least one run in seven of his last eight appearances with the Giants as favorites.
  • Willy Adames has hit a home run in four of his last five appearances against the Reds after playing the previous day.
  • Jung Hoo Lee has recorded at least one Double in each of his last six appearances after playing the previous day.
  • Logan Webb has recorded five or more strikeouts in each of his last 11 appearances with the Giants as favorites against NL Central opponents.
  • Willy Adames has recorded at least one RBI in each of his last six appearances against the Reds after playing the previous day.
  • Matt Chapman has recorded a Single in each of the Giants’ last six games against NL opponents that held a losing record.
  • Logan Webb has recorded a win in three of his last four appearances in night games.

Cincinnati Reds Player Prop Facts

  • Hunter Greene has recorded eight or more strikeouts in four of his last five appearances against NL West opponents.
  • Spencer Steer has recorded at least one RBI in each of the Reds’ last four road games against NL West opponents.
  • TJ Friedl has recorded at least one Single in nine of the Reds’ last 10 road games against opponents that held a winning record.
  • Hunter Greene has recorded a win in each of his last four appearances in night games against teams that held a winning record.
  • Gavin Lux has recorded at least one hit in eight of his last nine appearances with his team as an underdog against NL West opponents.
  • Gavin Lux has scored at least one run in five of his last six road appearances against NL West opponents.
  • Spencer Steer has hit a home run in each of the Reds’ last two night games against NL West opponents that held a winning record.

Matchup/League Facts

  • The Reds rank 30th in the league for walks this season (22).
  • The Reds rank 28th in the league for on-base percentage this season (.269).

Giants vs Reds Prediction 

San Francisco rolls into this matchup with one of the best records in the MLB through nine games and they have scored at least five runs in three of their last four. Cincinnati has dropped five of their last six games, which included three straight 1-0 losses, and the offense has been a huge problem for them this season. Both of these starting pitchers are very good and have looked solid to start the year, but I have to side with the Giants at home, as I can’t trust the Cincinnati offense. 

David Racey's Free Pick: Giants ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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