Guardians vs Cardinals Prediction 6/28/25 MLB Picks Today

In this article, we will formulate a Guardians vs Cardinals prediction for this MLB game on Saturday, June 28th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 40-40 this year after they lost game one by a score of 5-0 on Friday night. Cleveland fell behind in the third inning, and they never got their offense going for the shutout loss. The Guardians recorded just one hit, and they committed two errors in the game, while they were led by Jones, who went 1-3 in the loss. Cleveland started Ortiz, who allowed six hits and four earned runs over 7.0 innings for the loss, while Junis allowed one earned run in relief. 


Prior to this series, the Guardians lost two out of three against the Blue Jays, but did win two out of three against the Athletics before that. Cleveland has lost three of their last four games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 3.93 ERA with a 1.37 WHIP and a .251 opponent batting average, while the offense has scored 297 runs with a .227 batting average and a .298 on-base percentage this season. Jose Ramirez has led Cleveland with 13 home runs and 38 RBIs, while Kyle Manzardo has added 12 home runs and 32 RBIs this year. The projected starting pitcher for Cleveland is Slade Cecconi, who is 3-3 with a 3.38 ERA and a 1.29 WHIP over 37.1 innings pitched this year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 45-38 this season after they won game one to start this series on Friday. St. Louis jumped out to a 3-0 lead in the third inning, and they added one in the sixth and one in the eighth to seal the win. The Cardinals recorded seven hits in the game, and they were led by Burleson and Arenado, who both had two RBIs in the win. St. Louis started Gray, who allowed one hit and zero earned runs over 9.0 innings for the complete game shutout. 

Prior to this series, the Cardinals split four games with the Cubs and won two out of three against the Reds. St. Louis has won eight of their last eleven games, and they are currently third in the NL Central standings. The St. Louis pitching staff has a 3.93 ERA with a 1.25 WHIP and a .250 opponent batting average, while their offense has scored 387 runs with a .253 batting average and a .324 on-base percentage this season. Wilson Contreras has led St. Louis with 10 home runs, 50 RBIs, and three stolen bases, while Nolan Arenado has added 10 home runs and 41 RBIs this year. The projected starting pitcher for St. Louis is Miles Mikolas, who is 4-5 with a 4.31 ERA and a 1.28 WHIP over 77.1 innings pitched this season. 

Why the Guardians will beat the Cardinals

Why the Cardinals will beat the Guardians

Total Runs Facts

Cleveland Guardians Player Prop Facts

St. Louis Cardinals Player Prop Facts

Guardians vs Cardinals Prediction 

Cleveland comes into this matchup as a slight favorite to get the win, but they have scored a total of zero runs in their last two games. The Guardians are 20-18 at home this season, while the Cardinals are 19-21 on the road. St. Louis has been shut out in two of their last three games, so neither team is hitting the ball very well right now. Mikolas has been pretty solid for St. Louis in his last two starts, while Cecconi has allowed two earned runs or fewer in four straight. Take the under here. 

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