Guardians vs Orioles Prediction 4/16/26 MLB Picks Today

In this article we will formulate a Guardians vs Orioles prediction for this MLB game on Thursday, April 16th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 10-9 this season after they lost two out of three against the Cardinals by scores of 9-3, 5-6, and 3-5. In game three, Cleveland led 1-0 in the first inning, but they allowed the next four runs and never recovered in the loss. The Guardians recorded eight hits in the game and they were led by Naylor, who went 1-3 with two RBIs. Cecconi allowed three hits and one earned run over 4.0 innings, while Brogdon allowed three earned runs and was charged with the loss in relief. Prior to that series, Cleveland lost two out of three against the Braves, but did win two out of three against the Royals before that. 

This season, Cleveland has a 4.06 ERA with a 1.32 WHIP and a .236 opponent batting average, while they have scored 75 runs with a .229 batting average and a .314 on base percentage. Chase DeLauter has led the Guardians with five home runs and 12 RBIs, while Jose Ramirez has added three home runs and eight RBIs. The projected starting pitcher for Cleveland is Parker Messick, who is 2-0 with a 0.51 ERA and a 0.91 WHIP over 17.2 innings pitched this season. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 9-9 this year after they lost two out of three against the Diamondbacks by scores of 9-7, 3-4, and 5-8. In game three, Baltimore led 1-0 and 4-3, but they couldn’t hold either lead and couldn’t score in the 10th in the loss. The Orioles recorded eight hits in the game and they were led by Jackson, who went 2-5 with one home run and three RBIs. Bradish allowed eight hits and four earned runs over 6.0 innings, while Wells allowed two earned runs in the 10th for the loss. Prior to that series, Baltimore won two out of three against the Giants and all three against the White Sox. 

This season, Baltimore has a 3.99 ERA with a 1.33 WHIP and a .253 opponent batting average, while they have scored 77 runs with a .245 batting average and a .334 on base percentage. Gunnar Henderson has led the Orioles with six home runs and 13 RBIs, while Jeremiah Jackson has added four home runs and 14 RBIs. The projected starting pitcher for Baltimore is Shane Baz, who is 0-1 with a 4.50 ERA and a 1.56 WHIP over 16.0 innings pitched this year. 

Why the Cleveland Guardians will win

Why the Baltimore Orioles will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Baltimore Orioles Player Prop Facts

Guardians vs Orioles Prediction 

Both of these teams come into this series on a two game losing streak, with one of those losses coming in extra innings. The Guardians are 4-2 at home this year, while the Orioles are 3-3 on the road. Baltimore has scored 5+ runs in four of their last five games, but they are facing Messick, who has allowed one earned run over 17.2 innings. Cleveland has scored 5+ runs in three of their last five and they are facing Baz, who has allowed 3, 1, and 4 earned runs in his three starts. Take the Guardians at home, as Messick is red hot right now. 

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