Guardians vs Phillies Prediction 5/10/25 MLB Picks Today

The Philadelphia Phillies and the Cleveland Guardians meet Saturday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Guardians vs Phillies Prediction.

Starting Pitching Matchup

The Philadelphia Phillies will start Ranger Suarez here and Suarez is 0-0 with a 17.18 ERA and 6 strikeouts this season. This will be Suarez’s second career start against the Guardians. Tanner Bibee will start for the Guardians here and is 3-2 with a 4.26 ERA and 28 strikeouts this season. This will be Bibee’s second career start against the Phillies.

Philadelphia Phillies Recap

The Philadelphia Phillies come into this game looking to rebound after a 6-0 loss to the Guardians on Friday to fall to 22-16 on the year. After this series, the Phillies will head home for a set against the St. Louis Cardinals.

Phillies Have Three-Game Win Streak Snapped

Nick Castellanos has 39 hits with 10 doubles including 4 home runs and 21 RBIs while Kyle Schwarber has 35 hits with a team-high 12 home runs and 28 RBIs as well on the year. Bryce Harper has 6 stolen bases, 6 home runs and 20 RBIs. Trea Turner also has 44 hits with a team-high 9 stolen bases. Max Kepler has 7 doubles and Bryson Stott has 5 doubles, 2 triples, 3 homers and 20 RBIs while Stott also has 7 stolen bases as well this season.

Why the Philadelphia Phillies will win

• The Phillies have won 10 of their last 11 night games against American League opponents.
• The Guardians have lost each of their last six Saturday night games against National League opponents.
• The Phillies have covered the run line in each of their last seven games as road favorites against American League opponents following a loss.
• The Guardians have failed to cover the run line in seven of their last nine games as underdogs following a home win.

Philadelphia Phillies Player Prop Facts

• Bryce Harper has recorded a Double in three of the Phillies’ last four road games against AL Central opponents.
• Kyle Schwarber has hit at least one home run in five of his last eight appearances with the Phillies against AL opponents.
• J.T. Realmuto has recorded at least one RBI in three of his last four road appearances against the Guardians.
• Trea Turner has scored a run in each of his last seven Saturday night appearances against AL teams that held a winning record.
• Ranger Suarez has recorded five or more strikeouts in nine of his last 10 appearances in night games against teams that held a winning record.
• Trea Turner has recorded at least one Single in each of the Phillies’ last eight games.
• Brandon Marsh has recorded at least one hit in each of his last 10 road appearances against AL opponents.
• Kyle Schwarber ranks T1st in the league in Home Runs (12) this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to build on their win from the series opener on Friday. After this series, the Guardians will square off against the Milwaukee Brewers.

Guardians Win Three In A Row

Steven Kwan leads the Guardians with 49 hits as part of a .333 batting average and 4 home runs, 7 doubles and 17 RBIs. Kyle Manzardo has 23 hits with 3 doubles, a triple, 8 home runs and a team-high 21 RBIs as well this year. Gabriel Arias has a team-high 7 doubles but also 33 strikeouts and Manzardo has a team-high 33 strikeouts so far this season. Arias has also added 4 home runs and 16 RBIs and Jose Ramirez has chipped in 5 home runs and 17 RBIs.

Why the Cleveland Guardians will win

• The Guardians have won eight of their last 10 games as underdogs against the Phillies.
• The Phillies have lost four of their last six games as favorites against AL Central opponents.
• The underdogs have covered the run line in each of the Guardians’ last five games at Progressive Field.
• The Phillies have failed to cover the run line in four of their last five games at Progressive Field.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians’ last four home games against NL opponents.
• Jose Ramirez has recorded an RBI in each of the Guardians’ last four games as home underdogs against NL East opponents.
• Steven Kwan has scored at least one run in each of the Guardians’ last six night games against opponents that held a winning record.
• Steven Kwan has recorded at least one Single in each of his last 13 appearances against NL East opponents.
• Lane Thomas has recorded at least one hit in each of his last eight appearances against NL East opponents that held a winning record.
• Steven Kwan ranks 3rd in the league in Hits (50) this season.

Total Runs Facts

• Seven of the Guardians’ last eight games as underdogs against NL East opponents have gone UNDER the total runs line.
• Each of the Phillies’ last four games as favorites against the Guardians have gone UNDER the total runs line.

Guardians vs Phillies Prediction

I’m on the Phillies here. I get the case to be made for the Guardians, who are playing well right now. But the thing is that I don’t think that Ranger Suarez was as bad as his season debut would’ve indicated if you looked at that box score. He still has solid strikeout stuff, and the Guardians have been one of the less effective teams against left-handed pitching as of late.

Bibee hasn’t been as sharp as you’d expect from a staff ace, as he’s expected to be for Cleveland this season. The Guardians have still been doing a solid job against right-handed pitching as of late, despite a goose egg on Friday. I’ll roll with Philadelphia for the bounce back win here.