Guardians vs Tigers Prediction 9/24/25 MLB Picks Today

In this article we will formulate a Guardians vs Tigers prediction for this MLB game on Wednesday, September 24th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 85-72 this season after they won game one by a score of 5-2 on Tuesday night. Cleveland trailed 2-0 in the sixth inning, but scored three runs in the inning and added two more in the seventh to seal the win. The Guardians recorded seven hits in the game and they were led by Schneemann, who went 1-1 with two RBIs in the win. Cleveland started Williams, who allowed four hits and two earned runs over 6.0 innings for the win, while Smith picked up the save. 

Prior to this series, the Guardians won three out of four against the Twins and all three against the Tigers. Cleveland has won 11 of their last 12 games and they are now first in the AL Central standings. The Cleveland pitching staff has a 3.69 ERA with a 1.27 WHIP and a .239 opponent batting average, while the offense has scored 621 runs with a .226 batting average and a .297 on base percentage this season. Jose Ramirez has led Cleveland with 30 home runs and 82 RBIs, while Kyle Manzardo has added 26 home runs and 68 RBIs this year. The projected starting pitcher for Cleveland is Tanner Bibee, who is 11-11 with a 4.34 ERA and a 1.23 WHIP over 176.1 innings pitched this season. 

Detroit Tigers Betting Preview

The Detroit Tigers are 85-72 this year after they dropped game one by a score of 5-2 last night. Detroit led 2-0 in the sixth inning, but they fell apart and picked up yet another loss. The Tigers recorded five hits and they committed one error in the game, while they were led by Greene and Perez, who both had one RBI in the loss. Detroit started Skubal, who allowed four hits and one earned run over 6.0 innings for the loss, while Kahnle and Finnegan allowed one earned run in relief. 

Prior to this series, the Tigers lost all three against the Braves and all three against the Guardians. Detroit has lost 10 of their last 11 games and they are second in the AL Central standings. The Detroit pitching staff has a 3.98 ERA with a 1.25 WHIP and a .242 opponent batting average, while the offense has scored 745 runs with a .247 batting average and a .316 on base percentage this season. Riley Greene has led Detroit with 35 home runs and 110 RBIs, while Spencer Torkelson has added 31 home runs and 78 RBIs this year. The projected starting pitcher for Detroit is Jack Flaherty, who is 8-14 with a 4.60 ERA and a 1.28 WHIP over 156.2 innings pitched this year. 

Why the Guardians will beat the Tigers

Total Runs Facts

Cleveland Guardians Player Prop Facts

Detroit Tigers Player Prop Facts

Matchup/League Facts

Guardians vs Tigers Prediction 

Cleveland was able to work some magic to get the win in game one of this series and they have reclaimed the AL Central lead. The Guardians are 42-34 at home this year, while the Tigers are 39-37 on the road. Detroit is in the middle of a generational collapse and they are starting Flaherty, who has allowed one earned run or fewer in three of his last four starts. Cleveland is starting Bibee, who has allowed two earned runs or fewer in three straight. This should be another very tightly contested game, but I don’t see how we can take the Tigers right now. Take Cleveland to win. 

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