Guardians vs White Sox Prediction 4/8/25 MLB Picks Today

The Chicago White Sox and Cleveland Guardians meet on Tuesday in MLB action at Progressive Field. Here’s a Guardians vs White Sox Prediction. This article will include a Guardians vs White Sox Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 2-7 on the year and play the Red Sox, Athletics, and Twins next. The Chicago White Sox are batting .211 on the season, have a .273 OBP, and a .344 slugging percentage. The Chicago White Sox pitching staff has a 4.02 ERA and a 1.29 WHIP. Andrew Benintendi leads the Chicago White Sox with 9 hits and 6 RBI, while Brooks Baldwin and Luis Robert Jr. have combined for 12 hits and 6 RBI.

Shane Smith gets the ball for the Chicago White Sox, and he is 0-0 with a 3.18 ERA and 3 strikeouts this season. This will be Smith’s first career game against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 3-6 on the year and play the Royals, Orioles, and Pirates next. The Cleveland Guardians are batting .221 on the season and have a .300 OBP and a .400 slugging percentage. The Cleveland Guardians’ pitching staff has a 5.09 ERA and a 1.54 WHIP. Steven Kwan leads the Cleveland Guardians with 12 hits and 3 RBI, while Carlos Santana and Jose Ramirez have combined for 17 hits and 9 RBI.

Ben Lively gets the ball for the Cleveland Guardians, and he is 0-1 with a 6.75 ERA and 7 strikeouts this season. Lively is 1-1 with a 3.95 ERA and 10 strikeouts in his career against the Chicago White Sox.

Why the Cleveland Guardians will win

• The Guardians have won each of their last 10 home games against the White Sox following a road loss.
• The White Sox have lost 12 of their last 13 road games against AL Central opponents that held a losing record.
• The Guardians have covered the run line each of their last six day games against teams that held a losing record.
• The White Sox have failed to cover the run line in nine of their last 10 games against AL Central opponents that held a losing record.
• The Guardians have led after 3 innings in each of their last five day games against opponents that held a losing record.
• The Guardians have led after 5 innings in each of their last six games against AL Central opponents that held a losing record.
• The White Sox have lost the first inning in each of their last three games against AL Central opponents that held a losing record.

Why the Chicago White Sox will win

• The White Sox have won three of their last four games as underdogs against the Guardians following a road loss.
• The Guardians have lost five of their last six games.
• The Guardians have failed to cover the run line in eight of their last nine home games against AL Central opponents that held a losing record.
• The White Sox have covered the run line in each of their last seven Tuesday road games against AL Central opponents.
• The White Sox have won the first inning in four of their last five games against opponents that held a winning record at Progressive Field.
• The White Sox have led after 3 innings in three of their last four games at Progressive Field against AL Central opponents that held a losing record.
• The Guardians have trailed after 5 innings in six of their last seven games as home favorites against AL Central opponents.

Guardians vs White Sox Prediction

The Guardians aren’t off to the best of starts, and it is a concern. That pitching needs to improve. With that said, the Guardians will make their home debut, and that should help settle down the club. Also, the White Sox are looking more and more like the worst team in baseball, yet again. Smith will also make just his second big league start, and it’s on the road. Don’t love it. If the Guardians can’t get it right at home against possibly the worst team in baseball, then you start to hit the panic button. Give me the Guardians and the RL for max betting value.