Guardians vs White Sox Prediction 4/9/25 MLB Picks Today

The Chicago White Sox and Cleveland Guardians meet on Wednesday in MLB action at Progressive Field. Here’s a Guardians vs White Sox Prediction. This article will include a Guardians vs White Sox Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 2-8 on the year and play the Red Sox, Athletics, and Twins next. The Chicago White Sox are batting .199 on the season, have a .268 OBP, and a .321 slugging percentage. The Chicago White Sox pitching staff has a 3.75 ERA and a 1.26 WHIP. Andrew Benintendi leads the Chicago White Sox with 9 hits and 6 RBI, while Brooks Baldwin and Luis Robert Jr. have combined for 13 hits and 6 RBI.

Sean Burke gets the ball for the Chicago White Sox, and he is 1-1 with a 5.23 ERA and 4 strikeouts this season. This will be Burke’s second career game against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 4-6 on the year and play the Royals, Orioles, and Pirates next. The Cleveland Guardians are batting .211 on the season and have a .298 OBP and a .375 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.55 ERA and a 1.46 WHIP. Steven Kwan leads the Cleveland Guardians with 12 hits and 3 RBI, while Carlos Santana and Jose Ramirez have combined for 20 hits and 9 RBI.

Logan Allen gets the ball for the Cleveland Guardians, and he is 0-1 with a 6.75 ERA and 1 strikeout this season. Allen is 2-2 with a 4.28 ERA and 25 strikeouts in his career against the Chicago White Sox.

Why the Cleveland Guardians will win

• The White Sox have lost each of their last 14 night games against AL Central opponents.
• The Guardians have won seven of their last eight games against the White Sox.
• The White Sox have failed to cover the run line in each of their last nine night games against AL Central opponents.
• The Guardians have covered the run line in six of their last seven games against AL Central opponents that held a losing record.
• The Guardians have led after 5 innings in six of their last seven games against AL Central opponents that held a losing record.
• The White Sox have lost the first inning in three of their last four games against AL Central opponents that held a losing record.
• The Guardians have led after 3 innings in four of their last five night games against AL Central opponents that held a losing record.

Why the Chicago White Sox will win

• The Guardians have lost seven of their last eight games as favorites against the White Sox following a home win.
• The White Sox have won six of their last eight night games against the Guardians following a road loss.
• The Guardians have failed to cover the run line in each of their last six games as favorites against AL Central opponents following a home win.
• The road team has covered the run line in seven of the last eight games between the White Sox and Guardians.
• The White Sox have won the first inning in each of their last four night games at Progressive Field.
• The Guardians have trailed after 5 innings in each of their last five night games at Progressive Field against AL Central opponents.

Guardians vs White Sox Prediction

Allen needs to get some reps under his belt to look like the pitcher he’s capable of being, as he wasn’t great in his season debut. The Guardians have underachieved as a team through 10 games. With that said, the White Sox are the White Sox, a team that’s dreadful across the board and is looking more and more like the team from last season.

With six straight losses and losses in eight of their last nine games, the White Sox are a tough sell already through 10 games. The White Sox have already been shut out twice this season. After a slow start, the Guardians need to take advantage of games like this to get back in the swing of things. Give me the Guardians and the RL for max betting value.