Guardians vs White Sox Prediction 9/15/26 MLB Picks Today

In this article we will formulate a Guardians vs White Sox prediction for this MLB game on Tuesday, September 15th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 76-75 this season after they lost game one by a score of 3-7 on Monday night. Cleveland pitched pretty well in the first five innings, but they fell apart in the sixth for the loss. The Guardians recorded seven hits and they committed one error in the game, while they were led by Fry, who went 1-2 with one home run and two RBIs. Williams allowed four hits and two earned runs over 5.0 innings for the loss, while Espino allowed one earned run in relief. Prior to this series, Cleveland won two out of three against the Twins, but lost two out of three against the Orioles before that. 


This season, Cleveland has a 3.79 ERA with a 1.26 WHIP and a .237 opponent batting average, while they have scored 618 runs with a .237 batting average and a .314 on base percentage. Chase DeLauter has led the Guardians with 14 home runs and 62 RBIs, while Angel Martinez has added 15 home runs and 53 RBIs. The projected starting pitcher for Cleveland is Foster Griffin, who is 15-5 with a 3.65 ERA and a 1.18 WHIP over 162.2 innings pitched this season. 

Chicago White Sox Betting Preview

The Chicago White Sox are 77-73 this year after they won game one by a score of 7-3 last night. Chicago scored six runs in the sixth inning and added one more in the ninth in the win. The White Sox recorded nine hits and they committed two errors in the game, while they were led by Vargas, who went 2-4 with one home run and two RBIs. Newcomb opened the game, while Burke got the win in bulk relief. Prior to this series, Chicago lost two out of three against the Cardinals and all three against the Pirates. 

This season, Chicago has a 4.11 ERA with a 1.31 WHIP and a .241 opponent batting average, while they have scored 702 runs with a .235 batting average and a .319 on base percentage. Colson Montgomery has led the White Sox with 31 home runs and 84 RBIs, while Miguel Vargas has added 31 home runs and 81 RBIs. The projected starting pitcher for Chicago is Davis Martin, who is 9-7 with a 4.05 ERA and a 1.31 WHIP over 135.2 innings pitched this year. 

Why the Cleveland Guardians will win

Why the Chicago White Sox will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Chicago White Sox Player Prop Facts

Matchup/League Facts

Guardians vs White Sox Prediction 

Cleveland comes into this matchup after alternating wins and losses over their last five games and they trail Chicago by 1.5 games in the AL Central. The Guardians are 36-40 at home this year, while the White Sox are 34-42 on the road. Chicago has lost three of their last five games, but they have scored 14 runs in their last three. The White Sox are starting Martin, who has allowed one earned run or fewer in three of his last five starts, while Griffin has allowed 8, 3, 2, 2, and 1 earned run in his last five. I know Griffin struggled last time out, but I still like Cleveland to win here. 

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