Guardians vs White Sox Prediction 7/10/25 MLB Picks Today

The Cleveland Guardians are visiting the Chicago White Sox on Thursday, July 10th at the Rate Field in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Guardians vs White Sox Prediction. We will examine:

The Chicago White Sox’s recent form and player performance


The Cleveland Guardians’ recent form and player performance

Recent betting trends and streaks involving the Chicago White Sox

Recent betting trends and streaks involving the Cleveland Guardians

Recent betting trends in games played between the Cleveland Guardians vs Chicago White Sox

A summary that ties it all together and produces a favorable betting outcome for the Cleveland Guardians vs Chicago White Sox game

Chicago White Sox Preview

The Chicago White Sox have a 31-62 record this season and are sitting in last place in the AL Central. The White Sox have a 20-26 home record and are 39-49 in over/under. They are coming off a 2-1 home victory over the Blue Jays, which snapped their previous three-game losing streak. Under is 8-2 in their last 10 games, and are playing the Pirates and the Rays next.

The White Sox have a .222 batting average this season, a .296 OBP, and a .345 Slugging percentage. Chicago’s pitching staff has a 4.14 ERA and 1.40 WHIP. Lenyn Sosa leads the White Sox with 74 hits, while Miguel Vargas leads the team in RBI with 34, and he is the team’s best hitter with a team-high .220 batting average

Jonathan Cannon (R) is the projected starter for the White Sox, and he has a 3-7 record, 4.50 ERA, and 1.46 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 43-48 record this season and are sitting in 4th place in the AL Central. The Guardians have a 23-25 road record and are 40-48 in over/under. They are coming off a 4-2 road victory over the Astros, sweeping that series 3-0. Over is 3-1 in their last 4 games, and they are playing the Orioles and the Athletics next.

The Guardians have a .224 batting average this season, .295 OBP, and .366 Slugging percentage. Cleveland’s pitching staff has a 3.97 ERA and 1.36 WHIP. Steven Kwan leads the Guardians with 101 hits, while Jose Ramirez is the team’s best hitter with a .301 batting average. He also leads the team both in RBI, with 45, and in home runs with 17.

Logan Allen (R) is the projected starting pitcher for the Guardians, and he has a 5-7 record, 4.07 ERA, and 1.43 WHIP.

Why the Chicago White Sox will win

Why the Cleveland Guardians will win

Total Runs Facts

Matchup/League Facts

Chicago White Sox vs Cleveland Guardians 7/10/25 MLB Pick & Prediction | MLB Betting Tips

Guardians vs White Sox Prediction

The Guardians are 9-1 in their last 10 overall meetings against the White Sox, and have swept their previous series this season by 3-0 wins and a combined 10-3 score. They have won their last four visits in Chicago, and Under is 4-1-1 in their last 6 meetings.

In this Guardians vs White Sox Prediction, the Guardians are coming as -130 road favorites. The Guardians are rightfully favored, as they have a far better overall record and more road wins than the White Sox have at home. Cleveland has a better bullpen and a better offense, and Allen’s previous start against the White Sox this season was a shutout, while Cannon had 6 earned runs in his previous start against Cleveland. The value here lies with the road team at a good price, so take the Cleveland Guardians on the moneyline.

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