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Houston Astros vs Arizona Diamondbacks 9/28/22 MLB Picks, Predictions, Odds

Arizona Diamondbacks (71-84) vs. Houston Astros (102-53)
September 28, 2022 8:10 pm EDT
The Line: Houston Astros -200 / Arizona Diamondbacks +168; Over/Under: +6.5
(Get latest betting odds)

The Arizona Diamondbacks and Houston Astros meet Wednesday in MLB action at Minute Maid Park. The Arizona Diamondbacks need a win after losing 4 of their last 5 games. The Houston Astros look for a win after winning 7 of their last 9 games.

The Arizona Diamondbacks have scored 9 runs in their last 3 games and 4 or more runs in 5 of their last 8 games. The Diamondbacks have won 5 of their last 7 games when scoring 4 or more runs. Christian Walker leads the Diamondbacks with 130 hits and 88 RBI, while Daulton Varsho and Ketel Marte have combined for 237 hits and 123 RBI. Zac Gallen gets the ball, and he is 12-3 with a 2.46 ERA and 180 strikeouts this season. Gallen is 1-0 with a 3.50 ERA and 19 strikeouts in his career against the Astros.


The Houston Astros have scored 27 runs in their last 3 games and 4 or more runs in 10 of their last 12 games. The Astros have won 7 straight games when scoring 4 or more runs. Jose Altuve leads the Astros with 152 hits and 57 RBI, while Alex Bregman and Kyle Tucker have combined for 275 hits and 195 RBI. Justin Verlander gets the ball, and he is 17-4 with a 1.82 ERA and 167 strikeouts this season. Verlander is 4-1 with a 2.14 ERA and 45 strikeouts in his career against the Diamondbacks.

The Diamondbacks are 42-95 in their last 137 road games and 4-9 in their last 13 Wednesday games. The Astros are 6-0 in their last 6 Wednesday games and 64-29 in their last 93 overall. The under is 5-1 in Diamondbacks last 6 overall. The under is 9-3-1 in Astros last 13 home games. The Diamondbacks are 1-4 in the last 5 meetings in Houston and 2-5 in the last 7 meetings.

Zac Gallen and plus money is tough to turn down, but as good as he’s been, it’s hard to trust the Arizona Diamondbacks given they find ways to lose more times than not. Also, as good as Gallen has been, it’s Justin Verlander who is going to win the CY Young, and he has a 1.78 ERA and .208 allowed batting average at home. The Houston Astros offense is also on fire right now. Hard to step in front of the home team here. Give me the Astros and the RL for max betting value.

Randy Chambers's Free Pick: Houston Astros -1.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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