Mariners vs Padres Prediction 5/18/25 MLB Picks Today

The Seattle Mariners are visiting the San Diego Padres on Sunday, May 18th at the Petco Park in the third game of this series, with the Mariners having a 2-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Mariners vs Padres Prediction. We will examine:

The San Diego Padres’ recent form and player performance

The Seattle Mariners’ recent form and player performance

Recent betting trends and streaks involving the San Diego Padres

Recent betting trends and streaks involving the Seattle Mariners

Recent betting trends in games played between the Seattle Mariners vs San Diego Padres

A summary that ties it all together and produces a favorable betting outcome for the Seattle Mariners vs San Diego Padres game

San Diego Padres Preview

The San Diego Padres have a 27-17 record this season and are sitting in second place in the NL West. They have a 16-7 home record, and are 19-24 in over/under. The Padres are coming off a 1-4 home defeat by the Mariners, having lost both games of this home series. Under is 3-0 in their last 3 games, and they are playing the Braves and the Blue Jays next.

The Padres have a .262 batting average this season, a .330 OBP, and a .398 Slugging percentage. San Diego’s pitching staff has a 3.36 ERA and 1.17 WHIP.  Manny Machado leads the Padres with 52 hits and a team-high .323 batting average. Fernando Tatis Jr leads the team both in RBI, with 26, and in home runs, with 11.

Michael King (R) will take the mound for the Padres, and he has a 4-1 record, 2.32 ERA, and 0.99 WHIP. He has been extremely good at home, with a 1.64 ERA in six home starts, and he has not given up more than two runs in his last six starts. Michael King is 0-2 with an ERA of 1.98 and 19 strikeouts in 4 appearances against the Mariners in his career.

Seattle Mariners Preview

The Seattle Mariners have a 25-19 record this season and are sitting in first place in the AL West. The Mariners have a 12-8 road record and 25-17 in over/under. They are coming off a 4-1 road victory over the Padres, and are 3-1 in their last 4 games. Under is 4-0 in their last 4 games, and they are playing the Astros and the White Sox next.

The Mariners have a .239 batting average this season, a .326 OBP, and a .402 Slugging percentage. Seattle’s pitching staff has a 3.78 ERA and 1.32 WHIP. Julio Rodriguez leads the Mariners with 42 hits, while JP Crawford is the team’s best hitter with a .270 batting average. Cal Raleigh leads the team both in RBI with 31 and in home runs with 15.

Bryan Woo (R) will take the mound for the Mariners, and he has a 4-1 record, 2.84 ERA, and 0.89 WHIP. He has been weaker on the road with a 4.02 ERA across five road starts, but he has two shutouts in his last three starts, with the most recent one being against the Yankees. In his only start against the Padres last season, he gave up two runs in 6.2 innings of work, as the Mariners won 6-2.

Why the San Diego Padres will win

Why the Seattle Mariners will win

Total Runs Facts

Matchup/League Facts

San Diego Padres vs Seattle Mariners 5/18/25 MLB Pick & Prediction | MLB Betting Tips

Mariners vs Padres Prediction

The Mariners are 9-2 in their last 11 meetings against the Padres, and have won their last four visits in San Diego in a dominant fashion, with a combined 19-5 score. They are up 2-0 in this series, having outscored the Padres by 9-2 runs. Under is 7-3-2 in their last 12 meetings.

In this Mariners vs Padres Prediction, the Padres are coming as -140 home favorites. The Padres are favored because they still have a better record this season, and they have the second-best home record in the National League. But the Mariners have been dominating them in this series, and are putting their best pitcher on the mound. Both teams score exactly 5.1 runs against righties, so this line feels a bit inflated towards the Padres.

With both pitchers being terrific this season, I will not pick a side and instead look for another low-scoring game. Both pitchers have a combined 5.16 ERA and have a WHIP below 1.00, and their deeper analytics do not show a negative regression coming. Both teams are a perfect 7-0 to the under in their last 7 games combined, and the two games of this series had a 5.5 average total runs. Take the under 7.5 in this one.

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