Mets vs Padres Prediction 9/16/25 MLB Picks Today

In this article we will formulate a Mets vs Padres prediction for this MLB game on Tuesday, September 16th at Citi Field in New York. Let’s take a look at the prediction for this MLB matchup. 

New York Mets Betting Preview

The New York Mets are 77-73 this season after they lost two out of three against Texas by scores of 3-8, 2-3, and 5-2. In their game three win, New York blew a 2-0 lead in the seventh, but scored three runs in the bottom of the 10th for the victory. The Mets recorded seven hits in the game and they were led by Alonso, who went 1-4 with one home run and three RBIs in the win. New York started McLean, who allowed five hits and zero earned runs over 6.0 innings, while Stanek got the win. 

Prior to that series, the Mets lost all four against the Phillies and two out of three against the Reds. New York has lost eight of their last nine games and they are second in the NL East standings. The New York pitching staff has a 4.01 ERA with a 1.34 WHIP and a .246 opponent batting average, while the offense has scored 704 runs with a .249 batting average and a .327 on base percentage this season. Pete Alonso has led New York with 34 home runs and 117 RBIs, while Juan Soto has added 40 home runs and 98 RBIs this year. The projected starting pitcher for New York is Clay Holmes, who is 11-8 with a 3.75 ERA and a 1.35 WHIP over 151.0 innings pitched this season. 

San Diego Padres Betting Preview

The San Diego Padres are 82-68 this year after they won three out of four against Colorado by scores of 2-0, 2-4, 11-3, and 9-6. In their game four win, San Diego nearly blew a 7-0 lead, but they added two insurance runs in the eighth to seal the victory. The Padres recorded 13 hits and they committed one error in the game, while they were led by Merrill, who went 2-5 with one home run and three RBIs in the win. San Diego started Darvish, who allowed four hits and three earned runs over 5.0 innings for the win, while Suarez picked up the save. 

Prior to that series, the Padres lost two out of three against the Reds, but did win two out of three against the Rockies before that. San Diego has split their last six games and they are second in the NL West standings. The San Diego pitching staff has a 3.64 ERA with a 1.20 WHIP and a .225 opponent batting average, while their offense has scored 641 runs with a .252 batting average and a .321 on base percentage this season. Manny Machado has led San Diego with 25 home runs and 88 RBIs, while Fernando Tatis has added 22 home runs and 65 RBIs this year. The projected starting pitcher for San Diego is Michael King, who is 4-2 with a 2.87 ERA and a 1.07 WHIP over 62.2 innings pitched this year. 

Why the Mets will beat the Padres

Total Runs Facts

New York Mets Player Prop Facts

San Diego Padres Player Prop Facts

Mets vs Padres Prediction 

Both of these teams come into this series fighting for playoff positioning, so this is a huge series for each side. San Diego is 35-40 on the road this year, while New York is 46-29 at home. The Mets are really struggling over the last two weeks and they are starting Holmes, who has allowed two earned runs or fewer in four of his last five outings. SD is going with King, who has allowed two earned runs in four of his last five starts, but he has only pitched twice since May due to injury. This should be a fantastic game, but I have to side with New York at home. 

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