Brewers vs Cardinals Prediction 9/12/25 MLB Picks Today

The St. Louis Cardinals and the Milwaukee Brewers meet Friday in MLB action from American Family Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Brewers vs Cardinals Prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Andre Pallante for the start here and Pallante is 6-13 with a 5.28 ERA and 104 strikeouts this season. In his career, Pallante is 0-1 with a 7.71 ERA and 10 strikeouts against the Brewers. Milwaukee will send out Quinn Priester for the start here and Priester is 12-2 with a 3.25 ERA and 113 strikeouts this season. In his career, Priester is 1-0 with a 4.91 ERA and 5 strikeouts against St. Louis.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from a 4-2 loss at the hands of the Seattle Mariners last time out to sit at 72-75 this season. After this series, the Cardinals will head home for a series against the Cincinnati Reds.

Cardinals Lose Three In A Row

Brendan Donovan has a team-high 118 hits along with 25 doubles, 9 home runs and 45 RBIs while Lars Nootbaar has 109 hits with 13 home runs, 45 RBIs, 22 doubles and 4 stolen bases. Nolan Arenado also has 85 hits with 15 doubles, 10 home runs and 43 RBIs of his own and Victor Scott II has 81 hits with 14 doubles, a triple, 36 RBIs and a team-high 31 stolen bases. Willson Contreras has also chipped in 120 hits with 30 doubles, 20 home runs and 78 RBIs of his own as well this season. Masyn Winn’s added 124 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 124 hits with 21 doubles, 17 home runs and 62 RBIs.

Why the St. Louis Cardinals will win

St. Louis Cardinals Player Prop Facts

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to bounce back from their 6-3 loss at the hands of the Texas Rangers last time out to drop to 89-58 this season. After this series, the Brewers will take on the Los Angeles Angels in an interleague series at home.

Brewers Trying To Rebound From Sweep

Brice Turang has 154 hits with 18 home runs, 74 RBIs and 24 stolen bases while Jackson Chourio has 135 hits with a team-high 33 doubles, 18 stolen bases, 20 home runs and 72 RBIs and Sal Frelick has 141 hits as well as 3 triples, 10 home runs, 54 RBIs and 19 stolen bases so far this season. Christian Yelich also has 16 stolen bases with 27 homers and 93 RBIs while also adding 18 doubles. Yelich also has a team-high 153 strikeouts up to this point in the year. William Contreras has 17 homers and 71 RBIs as well this season. Joey Ortiz has chipped in 97 hits with 17 doubles, 7 home runs and 44 RBIs and Caleb Durbin also has 22 doubles with 10 homers and 47 RBIs. 

Why the Milwaukee Brewers will win

Milwaukee Brewers Player Prop Facts

Total Runs Facts

Brewers vs Cardinals Prediction

I’m on the Brewers here. Both teams are coming off of being swept, but I think the Brewers’ offense is in a much better place compared to where St. Louis’ offense is at right now. Milwaukee is also the only team going anywhere come playoff time, while the Cards just have some significant issues in terms of drumming up consistent offense. Give me the Brew Crew here.

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