Minnesota Twins vs Cleveland Guardians Prediction 9/21/25 MLB Picks Today

The Cleveland Guardians and the Minnesota Twins meet Sunday in MLB action from Target Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Minnesota Twins prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Joey Cantillo for the start here and Cantillo is 5-3 with a 3.27 ERA and 95 strikeouts this season. In his career, Cantillo is 0-2 with a 4.60 ERA and 17 strikeouts against Minnesota. The Minnesota Twins will send out Simeon Woods Richardson here and Woods Richardson is 7-4 with a 4.31 ERA and 95 strikeouts this season. In his career, Woods Richardson is 0-1 with a 2.49 ERA and 19 strikeouts against the Guardians.


Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their double-header sweep of the Twins from Saturday, winning game one 6-0 before an 8-0 win in game two to improve to 84-71 this season. After this series, the Guardians will head home for what’s become a massive series against the Detroit Tigers.

Guardians Win Streak Now In Double-Digits

Steven Kwan has 159 hits as part of a .272 batting average and 10 home runs, 27 doubles and 49 RBIs. Kyle Manzardo has 104 hits with 17 doubles, 2 triples, 26 home runs and 67 RBIs as well this year. Gabriel Arias has 22 doubles but also 146 strikeouts and Manzardo has 123 strikeouts so far this season. Arias has also added 11 home runs and 50 RBIs and Jose Ramirez has chipped in 29 home runs and 80 RBIs with 39 stolen bases as well. 

Why the Cleveland Guardians will win

Cleveland Guardians Player Prop Facts

Minnesota Twins Recap

The Minnesota Twins come into this game looking to salvage something here after the two losses on Saturday dropped them to 66-89 this season. After this series, the Minnesota Twins will head on the road for a set against the Texas Rangers.

Twins Drop 9 Of Last 11

Byron Buxton has 119 hits along with 18 doubles, a team-high 31 home runs and 76 RBIs with 22 stolen bases and 7 triples while Trevor Larnach’s chipped in 119 hits with 21 doubles, 16 home runs and 58 RBIs as well this season. Brooks Lee has contributed 105 hits with 14 doubles, 14 home runs and 58 RBIs and Matt Wallner has 22 homers and 40 RBIs as well. 

Why the Minnesota Twins will win

Minnesota Twins Player Prop Facts

Total Runs Facts

Cleveland Guardians vs. Minnesota Twins Prediction

I’m on the Guardians here. I just think that the Guardians, this is what they do. They play strong baseball in September and always give themselves a shot at the playoffs and the division. It’s in this team’s DNA. The Twins just look like they’ve given up and if you need proof of that, just look at the results from Saturday’s double-header. I’ll roll with Cleveland for the sweep here.

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