Nationals vs Cubs Prediction 3/28/26 MLB Picks Today

In this article, we will formulate a Nationals vs Cubs Prediction for this MLB matchup on Saturday, March 28th. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 0-1 record this season and are sitting in last place of the NL Central. They are coming off a 10-4 home defeat by the Nationals and their previous three games were an 8-3 home loss to the Yankees, a 15-6 home win over the Yankees, and a 12-0 home win over the Brewers in spring training.

The Cubs have a .235 batting average this season, .350 OBP and .294 Slugging percentage. Chicago’s pitching staff has a 8.00 ERA and 1.44 WHIP. Michael Busch is the team’s best hitter with a .750 batting average, while Pete Crow-Armstrong leads the team in RBI with 2.

Cade Horton (R) is the projected starting pitcher for the Cubs, and last season he had a 11-4 record, 2.67 ERA and 1.08 WHIP.

Washington Nationals Preview

The Washington Nationals have a 1-0 record this season and are sitting in first place of the NL East. They are coming off a 10-4 away win over the Cubs and their previous three games were a 2-0 home loss to the Orioles, an 8-1 away loss to the Orioles, and a 3-1 home win over the Mets in spring training.

The Nationals have a .297 batting average this season, .350 OBP and .568 Slugging percentage. Washington’s pitching staff has a 3.00 ERA and 1.56 WHIP. Joey Wiemer is the team’s best hitter with a 1.000 batting average. CJ Abrams leads the team in RBI with 2, and Jacob Young added a team-high one home run.

Miles Mikolas (R) is the projected starting pitcher for the Nationals, and last season he had an 8-11 record, 4.84 ERA and 1.32 WHIP.

Washington Nationals @ the Chicago Cubs Betting Trends: March 28, 2026

 

Why the Chicago Cubs will win

 

Why the Washington Nationals will win

Total Runs Facts

Chicago Cubs Player Prop Facts

Washington Nationals Player Prop Facts

Matchup/League Facts

Nationals vs Cubs Prediction

The Nationals have won their last three meetings against the Cubs, all of them on the road. Over is 3-1 in their last 4 meetings.

In this Nationals vs Cubs Prediction, the Cubs are coming as -220 home favorites. The Cubs looked awful in opening day, giving up 10 total runs to the Nationals and I don’t think they will drop a second straight game in front of their home crowd. Horton has been excellent last season and his only start against the Nationals last season was a quality one, with just one earned run in 5.1 innings pitched. On the flip side, Mikolas has been torched by the Cubs last season, having given up 12 runs in 11 innings pitched as a member of the Cardinals, with his team losing 12-1 and 11-3 both games. Take the Cubs on the runline for a bounce-back win.

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