Orioles vs Astros Prediction 8/21/25 MLB Picks Today

In this article we will formulate an Orioles vs Astros prediction for this MLB game on Thursday, August 21st at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 59-67 this year after they won both games against Boston by scores of 6-3 and 4-3. In their game two win, Baltimore trailed 1-0 in the third and they blew a 3-1 lead in the ninth, but they were able to get the win in extra innings. The Orioles recorded six hits and they committed one error in the game, while they were led by Basallo, Cowser, and Mountcastle, who all had one RBI in the win. Baltimore started Sugano, who allowed five hits and zero earned runs over 5.0 innings, while Cano picked up the win and Martin got the save. 

Prior to that series, the Orioles won two out of three against the Astros and two out of three against the Mariners. Baltimore has won six of their last seven games and they are currently last in the AL East standings. The Baltimore pitching staff has a 4.65 ERA with a 1.38 WHIP and a .261 opponent batting average, while their offense has scored 547 runs with a .240 batting average and a .305 on base percentage this season. Jackson Holliday has led Baltimore with 15 home runs and 48 RBIs, while Gunnar Henderson has added 15 home runs and 57 RBIs this year. The projected starting pitcher for Baltimore is Brandon Young, who is 1-6 with a 5.68 ERA and a 1.49 WHIP over 52.1 innings pitched this year. 

Houston Astros Betting Preview

The Houston Astros are 69-58 this season after they lost all three games against Detroit by scores of 0-10, 0-1, and 2-7. In their game three loss, Houston allowed the first seven runs and never had a chance in the loss. The Astros recorded five hits in the game and they were led by Dubon, who went 1-4 with one home run and two RBIs in the loss. Houston started Valdez, who allowed seven hits and seven earned runs over 5.0 innings for the loss, while Dubin, De Los Santos, and VanWey closed out the game. 

Prior to that series, the Astros lost two out of three against the Orioles, but did win two out of three against the Red Sox before that. Houston has lost four games in a row, but they are still first in the AL West standings. The Houston pitching staff has a 3.89 ERA with a 1.22 WHIP and a .233 opponent batting average, while their offense has scored 532 runs with a .253 batting average and a .318 on base percentage this season. Jose Altuve has led Houston with 22 home runs and 64 RBIs, while Yanier Diaz has added 17 home runs and 53 RBIs this year. The projected starting pitcher for Houston is Jason Alexander, who is 3-1 with a 4.74 ERA and a 1.33 WHIP over 43.2 innings pitched this season. 

Why the Orioles will beat the Astros

Why the Astros will beat the Orioles

Total Runs Facts

Baltimore Orioles Player Prop Facts

Houston Astros Player Prop Facts

Orioles vs Astros Prediction 

Houston limps into this series really struggling at the plate, as they have scored a total of two runs in their last four games. The Astros are 31-31 on the road this year, while the Orioles are 30-30 at home. Baltimore is playing some of their best baseball right now and they are starting Young, who has allowed two earned runs or fewer in three of his last four starts. Houston is going with Alexander, who has allowed two earned runs or fewer in four straight outings. Take the under in this game. 

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