Orioles vs White Sox Prediction 5/30/25 MLB Picks Today

The Chicago White Sox and the Baltimore Orioles meet Friday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Orioles vs White Sox Prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Sean Burke for the start here, and he is 3-5 with a 4.33 ERA and 39 strikeouts this season. This will be Burke’s first career start against the Orioles. Zach Eflin will get the start for Baltimore and is 3-2 with a 5.40 ERA and 18 strikeouts this season. In his career, Eflin is 2-1 with a 3.13 ERA and 16 strikeouts against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to build on their 9-4 win over the New York Mets from their last matchup to improve to 18-38 on the year. After this series, the White Sox will head home for a division set against the Detroit Tigers.

White Sox Snap Three-Game Losing Streak

Lenyn Sosa leads the White Sox with 52 hits, including 10 doubles and 17 RBIs. Andrew Benintendi has 25 hits, including 6 home runs, 20 RBIs, and a .234 batting average, while Miguel Vargas has a team-high 15 doubles, 8 home runs, and 26 RBIs. Brooks Baldwin has also added 16 RBIs, while Luis Robert Jr. has a team-high 21 stolen bases along with 20 RBIs so far this season. Andrew Vaughn has 5 home runs and 19 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

• The Orioles have lost each of their last nine games as home favorites.
• The underdogs have won 10 of the Orioles’ last 11 games at Oriole Park at Camden Yards.
• The Orioles have failed to cover the run line in each of their last nine games as home favorites.
• The White Sox have covered the run line each of their last six games against American League opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Miguel Vargas has recorded a Double in each of the White Sox’s last five games.
• Luis Robert has recorded an RBI in each of the White Sox’s last four games against AL opponents that held a losing record.
• Mike Tauchman has scored a run in each of his last four appearances against the Orioles.
• Mike Tauchman has recorded at least one Single in five of his last six appearances in night games.
• Luis Robert has recorded two hits in four of his last five appearances at Oriole Park at Camden Yards.
• Andrew Vaughn has hit a home run in two of his last three road appearances against the Orioles.
• Luis Robert ranks 1st in the league in Steals (21) this season.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to bounce back from their 6-4 loss at the hands of the St. Louis Cardinals last time out, to drop to 19-36 on the year. After this series, the Orioles will head on the road for a series against the Seattle Mariners.

Orioles Drop Back-To-Back Games

Cedric Mullins has 42 hits so far this season, as well as 9 doubles, 10 home runs, and 31 RBIs with 8 stolen bases and a .232 batting average, while Adley Rutschman has 37 hits with 7 doubles, 5 homers, and 15 RBIs. Jackson Holliday has 50 hits with 7 doubles, 2 triples, 6 homers, and 24 RBIs. Ryan Mountcastle has 44 hits with 13 doubles, 2 homers, and 15 RBIs, and Gunnar Henderson has a team-high 58 strikeouts as well this season. Ryan O’Hearn also chipped in 54 hits with 7 doubles and 9 home runs with 21 RBIs, and Heston Kjerstad added 4 homers and 16 RBIs.

Why the Baltimore Orioles will win

• The White Sox have lost each of their last seven night games against American League opponents following a road win.
• The Orioles have won each of their last four games against the White Sox following a loss.
• The White Sox have failed to cover the run line in seven of their last eight road games against AL East opponents following a win.
• The Orioles have covered the run line in each of their last four games against the White Sox following a loss.

Baltimore Orioles Player Prop Facts

• Ryan Mountcastle has recorded a Double in three of his last four appearances against the White Sox.
• Gunnar Henderson has hit a home run in five of the Orioles’ last six home games against AL Central opponents that held a losing record.
• Zach Eflin has recorded five strikeouts in three of his last four appearances against opponents that held a losing record.
• Ramon Urias has recorded at least one Single in each of his last six home appearances against AL opponents that held a losing record.
• Gunnar Henderson has scored at least one run in each of the Orioles’ last six home games against the White Sox.
• Ramon Urias has recorded at least one hit in each of his last 11 appearances.
• Zach Eflin has recorded a win in four of his last five home appearances against AL Central opponents that held a losing record.
• Gary Sanchez has recorded at least one RBI in each of his last four appearances with his team as a favorite against AL opponents.
• Ryan O’Hearn ranks 5th amongst qualified players for On Base Percentage (.427) this season.

Total Runs Facts

• Each of the White Sox’s last six night games against American League opponents have gone UNDER the total runs line.
• Seven of the Orioles’ last eight night games against American League opponents have gone UNDER the total runs line.

Orioles vs White Sox Prediction

I’m on the White Sox here. I don’t love the White Sox on most days, but the thing here is that the Orioles are borderline impossible to back at this price because of how bad they’ve been this season. The starting pitching is a big reason why the numbers are where they are. The White Sox were not expected to do a lot this season, but Burke has been a decent option, and this is more of a value play than anything. Give me the White Sox in this one.