The Milwaukee Brewers and San Diego Padres meet Wednesday in MLB action at Petco Park. Here’s a Padres vs Brewers Prediction. This article will include a Padres vs Brewers Pick.
Milwaukee Brewers Betting Preview
The Milwaukee Brewers are 95-63 on the year and play the Reds next. The Milwaukee Brewers are batting .259 on the season, have a .333 OBP, and a .405 slugging percentage. The Milwaukee Brewers pitching staff has a 3.63 ERA and a 1.23 WHIP. Brice Turang leads the Milwaukee Brewers with 162 hits and 77 RBI, while Sal Frelick and Christian Yelich have combined for 298 hits and 165 RBI.
Chad Patrick gets the ball for the Milwaukee Brewers, and he is 3-8 with a 3.66 ERA and 119 strikeouts this season. This will be Patrick’s second career game against the San Diego Padres.
San Diego Padres Betting Preview
The San Diego Padres are 87-71 on the year and play the Diamondbacks next. The San Diego Padres are batting .252 on the season, have a .320 OBP, and a .388 slugging percentage. The San Diego Padres pitching staff has a 3.65 ERA and a 1.20 WHIP. Luis Arraez leads the San Diego Padres with 175 hits and 61 RBI while Manny Machado and Fernando Tatis Jr. have combined for 322 hits and 159 RBI.
Dylan Cease gets the ball for the San Diego Padres, and he is 8-12 with a 4.64 ERA and 207 strikeouts this season. Cease is 1-1 with a 3.57 ERA and 24 strikeouts in his career against the Milwaukee Brewers.
Milwaukee Brewers @ San Diego Padres Betting Trends: September 24, 2025
- Probable Starting Pitcher: Dylan Cease Record this season: 8-12 ERA: 4.64
- Home Record: 7-3
- Last 5 against Brewers: 1-1
Why the San Diego Padres will win
- The Brewers have lost each of their last six games against teams that held a winning record.
- The Padres have won eight of their last nine day games against NL Central opponents.
- The Padres have covered the run line in each of their last nine day games against NL Central opponents.
- The Brewers have failed to cover the run line in each of their last eight road games.
- The Padres have won the first inning in four of their last five home games.
- The Brewers have trailed after 5 innings in seven of their last eight road games.
- The Padres have led after 3 innings in each of their last four games as home favorites.
- Probable Starting Pitcher: Chad Patrick Record this season: 3-8 ERA: 3.66
- Road Record: 1-4
- Last 5 against Padres: 0-1
Why the Milwaukee Brewers will win
- The Brewers have won each of their last six games as underdogs against NL West opponents.
- The Padres have lost four of their last five games as favorites against the Brewers following a home win.
- The Brewers have covered the run line in each of their last 11 games as underdogs following a loss.
- The Padres have failed to cover the run line in five of their last six games as favorites against NL Central opponents following a win.
- The Brewers have led after 3 innings in three of their last four games at Petco Park against opponents that held a winning record.
- The Padres have lost the first inning in each of their last three day games against National League opponents that held a winning record.
- The Brewers have led after 5 innings in six of their last eight games against NL West opponents.
Total Runs Facts
- Seven of the Brewers’ last eight games as underdogs against the Padres have gone OVER the total runs line.
- Each of the Padres’ last five games as favorites against the Brewers have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last eight games against National League opponents.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in 13 of the Brewers’ last 15 games as road underdogs.
San Diego Padres Player Prop Facts
- Jackson Merrill has hit a home run in three of the Padres’ last four games as home favorites.
- Dylan Cease has recorded six or more strikeouts in each of his last nine home appearances against NL opponents.
- Jose Iglesias has recorded at least one hit in each of his last 15 appearances in day games against NL Central teams that held a winning record.
- Dylan Cease has recorded a win in each of his last four appearances with the Padres as favorites against NL opponents.
- Luis Arraez ranks 4th in the league in Hits (175) this season.
Milwaukee Brewers Player Prop Facts
- Brice Turang has hit a home run in three of the Brewers’ last four day games against opponents that held a winning record.
- William Contreras has recorded at least one hit in each of his last 10 appearances with the Brewers as road underdogs against NL West opponents.
Matchup/League Facts
- The Padres rank 1st in the league for opponent batting average this season (.224).
- The Padres rank 1st in the league for hits allowed this season (1163).
- The Brewers rank 2nd in the league for hits this season (1396).
- The Brewers rank 2nd in the league for on-base percentage this season (.333).
Padres vs Brewers Prediction
It feels like the Brewers have sipped a little too much champagne this week, as they’ve been in a funk their last few games. While Patrick has had a strong season, he’s been hittable on the road with a 4.56 ERA and .268 allowed batting average. The Padres keep winning to put pressure on the Dodgers in the NL West. Cease has been solid this month, allowing 18 hits and 8 runs in his last 21 innings. In 82.1 home innings, Cease has a 3.72 ERA and .226 allowed batting average. The Padres are playing the better ball and look like the more motivated team with a few games to go. Give me the Padres.