Padres vs Cubs Prediction 4/14/25 MLB Picks Today

The Chicago Cubs and San Diego Padres meet on Monday in MLB action at Petco Park. Here’s a Padres vs Cubs Prediction. This article will include a Padres vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 11-7 on the year and play the Diamondbacks, Dodgers, and Phillies next. The Chicago Cubs are batting .256 on the season, have a .348 OBP, and a .439 slugging percentage. The Chicago Cubs pitching staff has a 4.02 ERA and a 1.35 WHIP. Kyle Tucker leads the Chicago Cubs with 23 hits and 18 RBI, while Seiya Suzuki and Michael Busch have combined for 36 hits and 25 RBI.

Jameson Taillon gets the ball for the Chicago Cubs, and he is 1-1 with a 6.06 ERA and 14 strikeouts this season. Taillon is 2-0 with a 2.19 ERA and 19 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 13-3 on the year and play the Astros, Tigers, and Rays next. The San Diego Padres are batting .283 on the season, have a .348 OBP, and a .423 slugging percentage. The San Diego Padres’ pitching staff has a 2.68 ERA and a 1.04 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 20 hits and 9 RBI, while Manny Machado and Luis Arraez have combined for 36 hits and 10 RBI.

Dylan Cease gets the ball for the San Diego Padres, and he is 1-1 with a 7.98 ERA and 18 strikeouts this season. Cease is 4-2 with a 2.38 ERA and 55 strikeouts in his career against the Chicago Cubs.

Why the San Diego Padres will win

• The Padres have won each of their last 10 games at Petco Park.
• The Cubs have lost each of their last seven night games against the Padres following a win.
• The Padres have covered the run line in each of their last eight games at Petco Park.
• The Cubs have failed to cover the run line in each of their last four night games against National League opponents following a win.
• The Padres have led after 3 innings in each of their last four night games against NL Central opponents.
• The Padres have led after 5 innings in each of their last seven home games.
• The Padres have won the first inning in four of their last five games as favorites against National League opponents.

Why the Chicago Cubs will win

• The Padres have lost eight of their last nine games as home favorites against the Cubs following a win.
• The Cubs have won each of their last four games as underdogs after playing the previous day.
• The Padres have failed to cover the run line in each of their last seven home games against the Cubs following a win.
• The Cubs have covered the run line each of their last five games at Petco Park against teams that held a winning record.
• The Padres have trailed after 3 innings in four of their last five games against National League opponents that held a winning record.
• The Padres have trailed after 5 innings in each of their last six games against NL Central opponents.
• The Padres have lost the first inning in each of their last four home games against opponents that held a winning record.

Padres vs Cubs Prediction

The Padres are going to be favored at home with the rest advantage, as they’re playing fabulous ball, and the Cubs are coming off a big series against the Dodgers. This could be a letdown spot for the Cubs. However, Cease hasn’t been good through three starts, and that includes allowing 13 hits and 10 runs in his last 10.1 innings.

The Cubs have scored four or more runs in 11 of their last 14 games, so this probably isn’t a spot where Cease gets his feet under him. Taillon has settled in after a bad season opener, as he’s allowed nine hits and five runs in his last 12 innings while striking out 13. We cashed a nice dog with the Cubs last night. I like the value of the plus money with them again.