Chicago Cubs (12-8) vs. San Diego Padres (14-4)
April 16, 2025 4:10 pm EDT
The Line: San Diego Padres -125 / Chicago Cubs 105; Over/Under: 7.5
(Get latest betting odds)
The Chicago Cubs and San Diego Padres meet Wednesday in MLB action at Petco Park. Here’s a Padres vs Cubs Prediction. This article will include a Padres vs Cubs Pick.
Chicago Cubs Betting Preview
The Chicago Cubs are 12-8 on the year and play the Diamondbacks, Dodgers, and Phillies next. The Chicago Cubs are batting .257 on the season, have a .345 OBP, and a .436 slugging percentage. The Chicago Cubs pitching staff has a 4.12 ERA and a 1.36 WHIP. Kyle Tucker leads the Chicago Cubs with 25 hits and 18 RBI, while Nico Hoerner and Pete Crow-Armstrong have combined for 41 hits and 20 RBI.
Matthew Boyd gets the ball for the Chicago Cubs, and he is 1-1 with a 1.59 ERA and 17 strikeouts this season. This will be Boyd’s second career game against the San Diego Padres.
San Diego Padres Betting Preview
The San Diego Padres are 14-4 on the year and play the Astros, Tigers, and Rays next. The San Diego Padres are batting .277 on the season, have a .346 OBP, and a .425 slugging percentage. The San Diego Padres pitching staff has a 2.59 ERA and a 1.09 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 23 hits and 12 RBI, while Luis Arraez and Manny Machado have combined for 42 hits and 12 RBI.
Nick Pivetta gets the ball for the San Diego Padres, and he is 2-1 with a 1.59 ERA and 18 strikeouts this season. Pivetta is 1-2 with a 4.74 ERA and 23 strikeouts in his career against the Chicago Cubs.
Why the San Diego Padres will win
- The Padres have won each of their last nine games as home favorites.
- The Cubs have lost each of their last six games at Petco Park following a win.
- The Padres have covered the run line in each of their last 10 games at Petco Park.
- The Cubs have failed to cover the run line in seven of their last eight road games following an extra-innings win.
- The Padres have led after 3 innings in each of their last five games as favorites against NL Central opponents.
- The Padres have led after 5 innings in eight of their last nine home games.
Why the Chicago Cubs will win
- The Cubs have won four of their last five games as underdogs after playing the previous day.
- The Padres have lost 12 of their last 18 games as home favorites following an extra-innings loss.
- The Cubs have covered the run line each of their last six Wednesday day games against NL West opponents that held a winning record.
- The Padres have failed to cover the run line in five of their last six day games against National League opponents that held a winning record.
- The Cubs have led after 3 innings in four of their last five road day games.
- The Padres have trailed after 5 innings in each of their last six day games against National League opponents that held a winning record.
Matchup/League Facts
- The Padres rank 2nd in the league for batting average this season (.277).
- The Padres rank 2nd in the league for ERA this season (2.59).
- The Cubs rank 1st in the league for runs scored this season (122).
- The Cubs rank 1st in the league for hits this season (182).
Padres vs Cubs Prediction
The Cubs have been a scrappy bunch through 20 games, and they’re going to be a team to watch. Boyd has also been strong this season, allowing 13 hits and three runs through 17 innings. However, the Padres have been arguably the most impressive team in baseball up to this point, and they’re not a team I’m excited to bet against. Pivetta has above-average stuff, and he’s allowed just three runs in 17 innings while striking out 18. I’m going to keep siding with the Padres as long as the tickets keep cashing.
