Padres vs Giants Prediction 8/21/25 MLB Picks Today

The San Francisco Giants and San Diego Padres meet Thursday in MLB action at Petco Park. Here’s a Padres vs Giants Prediction. This article will include a Padres vs Giants Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 61-66 on the year and play the Brewers, Cubs, and Orioles next. The San Francisco Giants are batting .232 on the season, have a .308 OBP, and a .374 slugging percentage. The San Francisco Giants pitching staff has a 3.72 ERA and a 1.28 WHIP. Heliot Ramos leads the San Francisco Giants with 129 hits and 53 RBI, while Jung Hoo Lee and Willy Adames have combined for 222 hits and 109 RBI.

Justin Verlander gets the ball for the San Francisco Giants, and he is 1-9 with a 4.23 ERA and 95 strikeouts this season. Verlander is 2-0 with a 2.95 ERA and 20 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 71-56 on the year and play the Dodgers, Mariners, and Twins next. The San Diego Padres are batting .251 on the season, have a .322 OBP, and a .385 slugging percentage. The San Diego Padres pitching staff has a 3.53 ERA and a 1.20 WHIP. Manny Machado leads the San Diego Padres with 143 hits and 74 RBI while Luis Arraez and Fernando Tatis Jr. have combined for 268 hits and 99 RBI.

Dylan Cease gets the ball for the San Diego Padres, and he is 5-11 with a 4.61 ERA and 171 strikeouts this season. Cease is 3-3 with a 3.11 ERA and 46 strikeouts in his career against the San Francisco Giants.

Why the San Diego Padres will win

Why the San Francisco Giants will win

San Diego Padres Player Prop Facts

San Francisco Giants Player Prop Facts

Padres vs Giants Prediction

Verlander has been sharper this month, which is cool to see, but he’s been a washed up 42-year-old for most of the season and the Giants have been a mess lately where the offense isn’t producing. Despite allowing just five earned runs in his last 17 innings, Verlander has lost all three starts due to a lack of run support. Cease has been more consistent, and he’s at his best at home, where he has a 3.61 ERA and .215 allowed batting average in 67.1 innings. It’s hard to make a case for the Giants in their current form. Give me the Padres.

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