Philadelphia Phillies vs St. Louis Cardinals Prediction 8/22/26 MLB Picks Today

The St. Louis Cardinals and the Philadelphia Phillies meet Saturday in MLB action from Citizens Bank Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Philadelphia Phillies prediction.

Starting Pitching Matchup

The St. Louis Cardinals did not have a starting pitcher announced at the time that this article was posted. Andrew Painter will get the start for the Phillies and is 2-8 with a 6.43 ERA and 71 strikeouts this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to rebound from a 7-6 loss at the hands of the Philadelphia Phillies on Friday to sit at 66-64 this season. After this series, the Cardinals will take on the Orioles in a series at home.

Cardinals Alternate Wins & Losses In 6 Straight

Entering Friday, Jordan Walker has 140 hits, 28 doubles, 26 home runs and 94 RBIs while Alec Burleson has 141 hits with 33 doubles, 21 home runs and 93 RBIs. JJ Wetherholt has 116 hits with 16 home runs and 46 RBIs while Ivan Herrera has 117 hits with 23 doubles, 14 home runs and 53 RBIs. Masyn Winn’s added 103 hits with 19 doubles and 51 RBIs and Nathan Church has 77 hits with 9 home runs and 41 RBIs this season.

Philadelphia Phillies Recap

The Philadelphia Phillies come into this game looking to add on to their win over the Cardinals on Friday to improve to 71-58 this season. After this series, the Phillies will head on the road for a series against the Seattle Mariners.

Phillies Win 7 Consecutive

Going into Friday, Kyle Schwarber has 111 hits with 15 doubles, 37 home runs and 74 RBIs. Brandon Marsh has 122 hits with 17 doubles, 17 home runs and 54 RBIs while Justin Crawford also has 93 hits with 17 doubles, 4 triples, 2 home runs and 31 RBIs. Trea Turner has 125 hits with 22 doubles, 17 home runs and 49 RBIs and Bryce Harper’s added 116 hits with 23 doubles, 25 home runs and 72 RBIs this season.

St. Louis Cardinals @ Philadelphia Phillies Betting Trends: August 22, 2026

 

Why the Philadelphia Phillies will win

 

Why the St. Louis Cardinals will win

Total Runs Facts

Philadelphia Phillies Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

St. Louis Cardinals vs. Philadelphia Phillies Prediction

I’m backing the Cardinals in this one. I get the case to be made for either side in this game, but I just do not trust Andrew Painter as a starting option right now at the Major League level, and I came into this one thinking that this was probably the Cardinals’ best shot at a win in this series. I think Painter struggles again and the Cards get it done. Give me St. Louis.

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