Phillies vs Diamondbacks Prediction 9/20/25 MLB Picks Today

In this article, we will formulate a Phillies vs Diamondbacks Prediction for this MLB game on Saturday, September 20th at the Chase Field in the second game of this series, with the Phillies having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 77-77 record this season and are sitting on the third place of the NL West. The Diamondbacks have a 40-36 home record and are 74-71 in over/under They are coming off a 2-8 home defeat by the Phillies, and have back-to-back losses. They are playing the Padres and the Dodgers next.

The Diamondbacks have a .250 batting average this season, .324 OBP and .434 slugging percentage. Arizona’s pitching staff has a 4.46 ERA and 1.31 WHIP. Geraldo Perdomo leads the Diamondbacks with 163 hits, adding a team-high 97 RBI. He Is also the team’s best hitter with a .289 batting average, while Corbin Carroll leads the team in home runs with 30.

Zac Gallen (R) is the projected starting pitcher for the Diamondbacks, and he has a 12-14 record, 4.73 ERA and 1.25 WHIP.

Philadelphia Phillies Preview

The Philadelphia Phillies have a 92-62 record this season and are sitting on the first place of the NL East. They have a 41-38 road record, and are 69-75 in over/under. They are coming off an 8-2 road victory over the Dbacks, and have four consecutive wins. They are playing the Twins and the Marlins next.

The Phillies have a .260 batting average this season, .330 OBP and .432 Slugging percentage. Philly’s pitching staff has a 3.84 ERA and 1.24 WHIP. Trea Turner leads the Phillies with 179 hits and he is the team’s best hitter, with a .305 batting average. Kyle Schwarber leads the team with 128 RBI and a team-high 53 home runs.

Aaron Nola (R) is the projected starting pitcher for the Phillies, and he has a 4-9 record, 6.44 ERA and 1.43 WHIP.

Philadelphia Phillies @ Arizona Diamondbacks Betting Trends: September 20, 2025

 

Why the Arizona Diamondbacks will win

 

Why the Philadelphia Phillies will win

Total Runs Facts

Arizona Diamondbacks Player Prop Facts

Philadelphia Phillies Player Prop Facts

Matchup/League Facts

Phillies vs Diamondbacks Prediction

The Phillies are 3-1 in their last 4 head-to-head meetings against the Diamondbacks, but the Dbacks are 3-1 in their last 4 meetings in Arizona. Over is 4-2 in their last 6 meetings.

In this Phillies vs Diamondbacks Prediction, the Diamondbacks are coming as -115 home favorites. Gallen has been in good form for the Dbacks lately, having one earned run or less in four of his last five starts, and he has been slightly better at home. On the flip side, Nola has been terrible for the Phillies this season, and has been atrocious on the road, with a 7.00 ERA. He has 6 earned runs in two of his last three starts, and I don’t trust him on the road against a Dbacks team fighting for a Wild Card spot. Take the Arizona Diamondbacks to get the job done at home in this one.

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