Pirates vs Astros Prediction 6/5/25 MLB Picks Today

The Houston Astros and the Pittsburgh Pirates meet Thursday in MLB action from PNC Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Pittsburgh Pirates prediction.

Starting Pitching Matchup

The Houston Astros will send out Framber Valdez for the start here, and Valdez is 5-4 with a 3.12 ERA and 73 strikeouts this season. In his career, Valdez is 2-1 with a 6.75 ERA and 17 strikeouts against the Pirates. The Pirates will trot out Mitch Keller for the start here, and Keller is 1-7 with a 3.73 ERA and 56 strikeouts this season. This will be Keller’s second career start against the Astros.

Houston Astros Recap

The Houston Astros come into this game looking to bounce back from a 3-0 loss at the hands of the Pirates in Wednesday’s matchup to drop to 33-28 on the year. After this series, the Astros will head on the road for a series against the Cleveland Guardians.

Astros Win 7 Of Their Last 10 Despite Wednesday’s L

Jose Altuve has 61 hits, including 9 home runs and 22 RBIs. Jeremy Pena also has 72 hits with 9 homers and 30 RBIs with 10 stolen bases, while Yordan Alvarez has 4 doubles and 18 RBIs with 21 strikeouts as well. Jake Meyers has 10 doubles as well, and Christian Walker has also accrued a team-high 69 strikeouts so far this season. Altuve also has 5 stolen bases, while Jake Meyers has 8 stolen bases this season. Isaac Paredes also has a team-high 12 home runs with 34 RBIs of his own, and Cam Smith has contributed 3 homers and 17 RBIs.

Why the Houston Astros will win

Houston Astros Player Prop Facts

Pittsburgh Pirates Recap

The Pittsburgh Pirates come into this game looking to build on their win over the Astros from Wednesday’s matchup to improve to 23-39 on the year. After this series, the Pirates will take on the Philadelphia Phillies at home.

Pirates Trying To Find Consistency

Bryan Reynolds has 55 hits with 9 doubles, 7 home runs, and 34 RBIs while also leading the Pirates with 67 strikeouts so far this season. Oneil Cruz has posted a team-high 12 home runs and 26 RBIs with 22 stolen bases, while Isiah Kiner-Falefa has 52 hits with 9 stolen bases. Emmanuel Valdez also has a pair of triples this season. Tommy Pham has 4 doubles and Andrew McCutchen has 46 hits with 9 doubles, and KeBryan Hayes has 48 hits with 18 RBIs and 6 stolen bases.

Why the Pittsburgh Pirates will win

Pittsburgh Pirates Player Prop Facts

Total Runs Facts

Houston Astros vs. Pittsburgh Pirates Prediction

I’m on the Astros in this one. I get the case to be made for the Pirates here as a home dog just based on value, but the thing is that the Pirates’ offense can be so wildly inconsistent that it’s just hard to trust them. On top of that, I just don’t trust Mitch Keller or this Pirates offense to back him up, or to match zeroes with Framber Valdez here. I’ll roll with Houston in this one.

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