Pirates vs Athletics Prediction 9/19/25 MLB Picks Today

The Athletics and Pittsburgh Pirates meet Friday in MLB action at PNC Park. Here’s a Pirates vs Athletics Prediction. This article will include a Pirates vs Athletics Pick.

Athletics Betting Preview

The Athletics are 72-81 on the year and play the Astros and Royals next. The Athletics are batting .255 on the season, have a .321 OBP, and a .435 slugging percentage. The Athletics pitching staff has a 4.72 ERA and a 1.36 WHIP. Brent Rooker leads the Athletics with 160 hits and 87 RBI, while Tyler Soderstrom and Jacob Wilson have combined for 295 hits and 149 RBI.


Luis Severino gets the ball for the Athletics, and he is 6-11 with a 4.82 ERA and 116 strikeouts this season. Severino is 3-1 with a 3.13 ERA and 16 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 65-88 on the year and play the Reds and Braves next. The Pittsburgh Pirates are batting .230 on the season, have a .304 OBP, and a .347 slugging percentage. The Pittsburgh Pirates pitching staff has a 3.87 ERA and a 1.23 WHIP. Bryan Reynolds leads the Pittsburgh Pirates with 134 hits and 71 RBI while Andrew McCutchen and Nick Gonzales have combined for 202 hits and 82 RBI.

Mitch Keller gets the ball for the Pittsburgh Pirates, and he is 6-14 with a 4.13 ERA and 140 strikeouts this season. Keller is 0-2 with a 6.97 ERA and 8 strikeouts in his career against the Athletics.

Athletics @ Pittsburgh Pirates Betting Trends: September 19, 2025

 

Why the Pittsburgh Pirates will win

 

Why the Athletics will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Athletics Player Prop Facts

Matchup/League Facts

Pirates vs Athletics Prediction

The Athletics continue to play hard and finish the season strong, which isn’t something you usually see from teams that aren’t in the playoff race. Severino also has a 3.11 ERA and .214 allowed batting average in 75.1 road innings. The Pirates look like a team ready for the offseason, as they’ve won one game since September 5. Keller has been dealing lately, allowing 4 earned runs in his last 16.2 innings, but it doesn’t matter given the Pirates effort overall. I’ll side with the A’s on the road.

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