Pirates vs Cardinals Prediction 9/23/26 MLB Picks Today

In this article we will formulate a Pirates vs Cardinals prediction for this MLB game on Wednesday, September 23rd at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 80-77 this season after they won game one by a score of 2-0 on Tuesday night. Pittsburgh scored once in the sixth and once in the seventh in the shutout win. The Pirates recorded five hits in the game and they were led by O’Hearn, who went 1-4 with one RBI. Jones allowed one hit and zero earned runs over 7.0 innings for the win, while Soto got the save. Prior to this series, Pittsburgh swept the Royals in three games, but lost two out of three against the Brewers before that. 


This season, Pittsburgh has a 4.16 ERA with a 1.30 WHIP and a .237 opponent batting average, while they have scored 750 runs with a .254 batting average and a .331 on base percentage. Brandon Lowe has led the Pirates with 33 home runs and 93 RBIs, while Ryan O’Hearn has added 18 home runs and 74 RBIs. The projected starting pitcher for Pittsburgh is TBD. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 76-81 this year after they lost game one by a score of 0-2 last night. St. Louis had plenty of issues generating baserunners and never scored in the loss. The Cardinals recorded one hit and they committed one error in the game, while they were led by Church, who went 1-3. Pallante allowed three hits and one earned run over 6.0 innings for the loss, while Bruihl picked up the loss. Prior to this series, St. Louis lost two out of three against the Nationals and two out of three against the Giants. 

This season, St. Louis has a 4.28 ERA with a 1.35 WHIP and a .253 opponent batting average, while they have scored 704 runs with a .241 batting average and a .314 on base percentage. Jordan Walker has led the Cardinals with 28 home runs and 100 RBIs, while Alec Burleson has added 23 home runs and 111 RBIs. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 5-14 with a 5.36 ERA and a 1.49 WHIP over 149.1 innings pitched this year. 

Why the Pittsburgh Pirates will win

Why the St. Louis Cardinals will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

Pirates vs Cardinals Prediction 

Pittsburgh comes into this matchup on a five game winning streak and they are making a push to finish the season above .500. The Pirates are 43-36 at home this year, while the Cardinals are 38-38 on the road. St. Louis has lost four of their last five games and they have allowed 6+ runs in three of those five. The Cardinals are starting Liberatore, who has allowed 1, 2, 5, 3, and 8 earned runs in his last five outings, while Pittsburgh is going with a bullpen game. Take the Pirates to win again here. 

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