Pirates vs Guardians Prediction 4/20/25 MLB Picks Today

In this article we will formulate a Pirates vs Guardians prediction for this MLB game on Sunday, April 20th at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 8-14 this year and they have lost the first two games in this series by scores of 10-7 and 3-0. In the game two loss, the Pirates were shutdown by the Cleveland pitching staff and couldn’t find any offense in the shutout loss. The Pirates recorded six hits in the game and they were led by Valdez and Cruz, who both had one walk and one hit in the loss. Pittsburgh started Skenes, who allowed six hits and two earned runs over 7.0 innings in the loss, while Ferguson allowed one hit and one earned run in one inning out of the bullpen. 

Prior to this series, the Pirates won three out of four against the Nationals, but did lose all three against the Reds before that. Pittsburgh has lost three of their last five games and they are currently last in the NL Central standings. The Pittsburgh pitching staff has a 4.06 ERA with a 1.24 WHIP and a .236 opponent batting average, while their offense has scored 74 runs with a .202 batting average and a .286 on base percentage this season. Oneil Cruz has led Pittsburgh with five home runs and 11 RBIs, while Bryan Reynolds has added three home runs and 10 RBIs this year. The projected starting pitcher for Pittsburgh is Mitch Keller, who is 1-2 with a 4.30 ERA and a 1.35 WHIP over 23.0 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 11-9 this season after they won game two in this series by a score of 3-0. Cleveland scored one run in the third, seventh, and eighth for the shutout victory. The Guardians recorded nine hits in the game and they were led by Kwan, Ramirez, and Manzardo, who all had one RBI in the win. Cleveland started Lively, who allowed four hits and zero earned runs over 5.1 innings in the win, while Smith, Herrin, Gaddis, and Clase completed the shutout. 

Prior to this series, the Guardians lost two out of three against the Orioles, but did win two out of three against the Royals before that. Cleveland has won three of their last five games and they are currently second in the AL Central standings. The Cleveland pitching staff has a 4.01 ERA with a 1.35 WHIP and a .248 opponent batting average, while the offense has scored 81 runs with a .239 batting average and a .312 on base percentage this season. Kyle Manzardo has led Cleveland with five home runs and 13 RBIs, while Steven Kwan has added three home runs and 12 RBIs this year. The projected starting pitcher for Cleveland is Logan Allen, who is 1-1 with a 2.30 ERA and a 1.40 WHIP over 15.2 innings pitched this season. 

Why the Pirates will beat the Guardians

Why the Guardians will beat the Pirates

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Cleveland Guardians Player Prop Facts

Pirates vs Guardians Prediction 

Cleveland comes into this matchup looking to complete the sweep in this series, as they have won the first two games by three runs each. The Guardians are 6-8 on the road this year, while the Pirates are 6-6 at home. Pittsburgh has scored one run or fewer in three of their last five games, so the offense has really let them down so far this year. The Pirates weren’t able to get a win with Skenes on the mound on Saturday, so they will turn to Mitch Keller, who has pitched well in three of his four starts so far. Cleveland is starting Logan Allen, who has allowed zero earned runs over his last two starts (10.1 IP). Take the under here. 

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