In this article, we will formulate a Red Sox vs Cardinals Prediction for this MLB matchup on Friday, April 10th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
St. Louis Cardinals Preview
The St. Louis Cardinals have a 7-5 record this season and are sitting in the third place of the NL Central. They have a 4-2 home record and are coming off a 6-1 road win against the Nationals. Their previous three games were a 7-6 road win against the Nationals, a 6-9 road loss, and a 5-3 road win against the Tigers.
The Cardinals have a .226 batting average this season, .324 OBP and .361 Slugging percentage. St. Louis’ pitching staff has a 4.95 ERA and 1.52 WHIP. Jordan Walker is the team’s best hitter with a .295 batting average, also leading the team in RBI with 12 and adding a team-high 5 home runs.
Dustin May (R) is the projected starting pitcher for the Cardinals, and he has a 0-2 record, 15.95 ERA and 2.73 WHIP.
Boston Red Sox Preview
The Boston Red Sox have a 4-8 record this season and are sitting in the fifth place of the AL East. They have a 1-5 away record and are coming off a 5-0 home win against the Brewers. Their previous three games were a 3-2 home win against the Brewers, a 6-8 and a 6-8 home loss against the Padres.
The Red Sox have a .226 batting average this season, .310 OBP and .356 Slugging percentage. Boston’s pitching staff has a 4.19 ERA and 1.35 WHIP. Wilyer Abreu is the team’s best hitter with a .383 batting average, also leading the team in RBI with 9 and adding a team-high 3 home runs.
Connelly Early (L) is the projected starting pitcher for the Red Sox, and he has a 0-0 record, 2.89 ERA and 1.50 WHIP.
Boston Red Sox @ St. Louis Cardinals Betting Trends: April 10, 2026
- Probable Starting Pitcher: Dustin May Record this season: 0-2 ERA: 15.95
- Home Record: 0-1
- Last 5 against Red Sox: 0-1
Why the St. Louis Cardinals will win
- The Red Sox have lost each of their last four games as road favorites.
- The Cardinals have won four of their last five games as home underdogs against American League opponents.
- The Red Sox have failed to cover the run line in each of their last 10 Friday night games as favorites against National League opponents.
- The Cardinals have covered the run line in six of their last seven night games against AL East opponents that held a losing record.
- The Red Sox have trailed after 5 innings in each of their last five road games against opponents that held a winning record.
- The Red Sox have lost the first inning in four of their last five road games.
- The Red Sox have trailed after 3 innings in each of their last four games at Busch Stadium against opponents that held a winning record.
- Probable Starting Pitcher: Connelly Early Record this season: 0-0 ERA: 2.89
- Road Record: 0-0
- Last 5 against Cardinals: –
Why the Boston Red Sox will win
- The Red Sox have won each of their last four games against the Cardinals.
- The Cardinals have lost five of their last six night games against AL East opponents.
- The road team has covered the run line in four of the Red Sox’s last five games.
- The Cardinals have failed to cover the run line in four of their last five night games against American League opponents following a win.
- The Red Sox have led after 3 innings in three of their last four games.
- The Cardinals have trailed after 5 innings in eight of their last nine night games at Busch Stadium against American League opponents.
- The Cardinals have lost the first inning in each of their last six night games against AL East opponents.
Total Runs Facts
- Eight of the Cardinals’ last nine night games against AL East opponents have gone OVER the total runs line.
- Five of the Red Sox’s last six games as favorites against National League opponents have gone UNDER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Red Sox’s last six games as favorites against National League opponents.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last six night games against AL East opponents.
St. Louis Cardinals Player Prop Facts
- Ramon Urias has recorded at least one hit in each of his last 10 appearances with his team as an underdog against the Red Sox.
- Nolan Gorman has hit a home run in each of his last two appearances against the Red Sox after not playing the previous day.
- Jordan Walker ranks T1st in the league in Home Runs (5) this season.
Boston Red Sox Player Prop Facts
- Trevor Story has recorded at least one hit in each of his last eight appearances against the Cardinals.
- Triston Casas has hit a home run in four of his last five road appearances against NL Central opponents.
- Wilyer Abreu ranks 2nd amongst qualified players for Slugging Percentage (.702) this season.
Matchup/League Facts
- The Cardinals rank 30th in the league for strikeouts this season (74).
- The Cardinals rank 29th in the league for opponent batting average this season (.268).
- The Red Sox rank T28th in the league for steals this season (4).
- The Red Sox rank 25th in the league for home runs this season (9).
Red Sox vs Cardinals Prediction
The Red Sox have won their last four meetings against the Cardinals but are 1-2 in their last three visits in Saint Louis.
In this Red Sox vs Cardinals Prediction, the Red Sox are coming as -149 road favorites. Both teams are coming off back-to-back wins but I don’t trust the Cardinals with Dustin May on the mound. He has been lit up this season with 13 earned runs in his two starts, while Early has been decent for Boston with a sub-3 ERA. On top of that, the Red Sox have a better bullpen, so I like the value with Boston in this spot. Take the Red Sox on the moneyline to get the job done in this one.