Red Sox vs White Sox Prediction 4/20/25 MLB Picks Today

The Chicago White Sox and the Boston Red Sox meet Sunday in MLB action from Fenway Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Red Sox vs White Sox Prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Sean Burke for the start here and Burke is 1-3 with a 7.56 ERA and 10 strikeouts this season. This will be Burke’s first career start against Boston. Tanner Houck will get the start for the Red Sox here and Houck is 0-2 with a 9.16 ERA and 11 strikeouts this season. In his career, Houck is 1-3 with a 5.60 ERA and 14 strikeouts against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back after ending up with a 4-3 loss in extra innings on Saturday to fall to 4-16 on the year. After this series, the White Sox will head on the road once again for a series against the Minnesota Twins.

White Sox Drop 6^th In A Row

Lenyn Sosa leads the White Sox with 18 hits including a pair of doubles and 8 RBIs. Andrew Benintendi has 10 hits including 3 home runs, 7 RBIs and a .244 batting average while Miguel Vargas has a team-high 4 doubles and 6 RBIs. Brooks Baldwin has also added 9 RBIs while Luis Robert Jr. has a team-high 6 stolen bases so far this season. Nick Maton also has a pair of home runs for the White Sox while Andrew Vaughn has 2 home runs and 8 RBIs as well this season.

Why the Chicago White Sox will win

• The Red Sox have lost three of their last four games as home favorites against American League opponents following a home win.
• The White Sox have won each of their last six Sunday games at Fenway Park.
• The Red Sox have failed to cover the run line in each of their last six day games against the White Sox at Fenway Park following a home win.
• The White Sox have covered the run line in eight of their last nine games against American League opponents after going to extra innings.

Chicago White Sox Player Prop Facts

• Luis Robert has hit at least one home run in five of his last seven appearances in day games against AL East teams that held a winning record.
• Luis Robert has recorded at least one RBI in six of his last seven appearances in day games against AL East teams that held a winning record.
• Luis Robert has scored a run in each of his last four appearances in day games against AL teams that held a winning record.
• Andrew Benintendi has recorded at least one hit in nine of his 10 previous appearances against the Red Sox after playing the previous day.
• Josh Rojas has recorded at least one Single in five of his last six appearances against the Red Sox.
• Luis Robert ranks T8th in the league in Steals (6) this season.

Boston Red Sox Recap

The Boston Red Sox come into this game looking to keep the momentum going after their win in Saturday’s matchup to improve to 12-10 on the year. After this series, the Red Sox will welcome the Seattle Mariners to town.

Red Sox Win 4^th In A Row

Trevor Story leads the Red Sox with 27 hits including a team-high 5 home runs and 14 RBIs along with a team-high 6 stolen bases. Alex Bregman has 25 hits with 7 doubles, 4 home runs and a team-high 16 RBIs while Jarren Duran has 21 hits with 4 doubles, a triple, a home run, 10 RBIs and 6 stolen bases of his own. Wilyer Abreu has 5 doubles, 3 home runs and 12 RBIs while Rafael Devers has 19 hits with 7 doubles of his own, 2 home runs and 12 RBIs but also has the dubious distinction of leading the Red Sox with 30 strikeouts so far this season.

Why the Boston Red Sox will win

• The White Sox have lost each of their last eight road games.
• The Red Sox have won each of their last five day games following a win.
• The White Sox have failed to cover the run line in five of their last six games.
• The Red Sox have covered the run line in each of their last five Sunday games against American League opponents.

Boston Red Sox Player Prop Facts

• Rafael Devers has hit a home run in five of his last six Sunday day appearances at Fenway Park.
• Alex Bregman has scored at least one run in each of his last six Sunday appearances with his team as a favorite.
• Trevor Story has recorded at least one Single in each of his last nine appearances against AL Central opponents.
• Trevor Story has recorded at least one hit in each of his last nine appearances against AL Central opponents.
• Connor Wong has recorded a Double in each of his last three appearances in day games against teams that held a losing record.
• Connor Wong has recorded an RBI in each of his last four appearances against AL Central opponents.
• Trevor Story ranks T7th in the league in Hits (27) this season.

Total Runs Facts

• Seven of the Red Sox’s last eight day games against AL Central opponents have gone UNDER the total runs line.
• Each of the White Sox’s last four day games against AL East opponents have gone UNDER the total runs line.

Red Sox vs White Sox Prediction

I’m on the Red Sox here. I think Houck is a better starter than what he showed in that last game, and the bulk of his starts this season have been on the road. But this is a rare instance where Houck gets a home start and a perfect bounce back spot against a White Sox team. I have to wonder if they’d even be able to hit themselves out of a wet paper bag at this point. The Red Sox have been the better team by a fair margin in this series, and I think they get to Burke in this one as the BoSox nab the win at home here.