Red Sox vs White Sox Prediction 4/21/25 MLB Picks Today

In this article we will formulate a Red Sox vs White Sox prediction for this MLB game on Monday, April 21st at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB matchup. 

Boston Red Sox Betting Preview

The Boston Red Sox are 12-11 this year and they have won two of the first three games in this series by scores of 10-3, 4-3, and 4-8. In the game three loss, the Red Sox led 4-2 in the second inning, but they were outscored 6-0 in the final seven innings for the loss. The Red Sox recorded six hits and they committed one error in the game, while they were led by Abreu, who went 1-4 with one home run and three RBIs in the loss. Boston started Houck, who allowed three hits and two earned runs over 6.0 innings, while Kelly allowed one hit and three earned runs without recording an out for the loss. 

Prior to this series, the Red Sox won two out of three against the Rays, but did lose two out of three against the White Sox before that. Boston has won four of their last five games and they are currently third in the AL East standings. The Boston pitching staff has a 4.12 ERA with a 1.29 WHIP and a .254 opponent batting average, while their offense has scored 104 runs with a .246 batting average and a .324 on base percentage this season. Alex Bregman has led Boston with four home runs and 16 RBIs, while Trevor Story has added five home runs and 14 RBIs this year. The projected starting pitcher for Boston is Walker Buehler, who is 2-1 with a 5.23 ERA and a 1.26 WHIP over 20.2 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 5-16 this season after they won game three by a score of 8-4 on Sunday. Chicago trailed 4-2 in the second inning, but they scored six runs in the final three innings for the win. The White Sox recorded nine hits and they committed two errors, while they were led by Thaiss, who went 1-4 with one home run and three RBIs in the win. Chicago started Burke, who allowed five hits and one earned run over 5.0 innings, while Eisert picked up the win in relief. 

Prior to this series, the White Sox lost all three against the Athletics, but did win two out of three against the Red Sox before that. Chicago has lost six of their last seven games and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.34 ERA with a 1.34 WHIP and a .236 opponent batting average, while the offense has scored 68 runs with a .198 batting average and a .272 on base percentage this season. Brooks Baldwin has led Chicago with two home runs and 10 RBIs, while Andrew Vaughn has added three home runs and 10 RBIs this year. The projected starting pitcher for Chicago is Jonathan Cannon, who is 0-2 with a 4.42 ERA and a 1.53 WHIP over 18.1 innings pitched this season. 

Why the Red Sox will beat the White Sox

Total Runs Facts

Boston Red Sox Player Prop Facts

Chicago White Sox Player Prop Facts

Matchup/League Facts

Red Sox vs White Sox Prediction 

Chicago was able to pick up a nice win on Sunday afternoon in game three of this series, but they are just 5-16 overall on the season and 1-8 on the road. Boston is 6-4 at home and they will be looking for their second straight series win with a victory here. The Red Sox are starting Buehler, who has allowed three earned runs in his last two starts (11.1 IP). Chicago is going with Cannon, who has allowed zero earned runs in two of his four starts, but has allowed a combined nine earned runs in the other two. You never know how Cannon is going to pitch, but I like how Buehler has looked in his last two games, so I will take Boston -1.5 here. 

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