In this article, we will formulate a Reds vs Brewers Prediction for this MLB game on Friday, September 26th at the American Family Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.
Milwaukee Brewers Preview
The Milwaukee Brewers have a 96-63 record this season and are sitting on the 1st place of the NL Central. The Brewers have a 51-27 home record and are 76-78 in over/under. They are coming off a 3-1 road victory over the Padres, that ended their three-game losing streak. Under is 4-1 in their last 5 games.
The Brewers have a .260 batting average this season, .333 OBP and .405 slugging percentage. Milwaukee’s pitching staff has a 3.61 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 165 hits, while Sam Frelick is the team’s best hitter, with a .291 batting average. Christian Yelich leads the team in RBI, with 102, adding a team-high 29 home runs.
Quinn Priester (R) is the projected starting pitcher for the Brewers, and he has a 13-2 record, 3.25 ERA and 1.21 WHIP.
Cincinnati Reds Preview
The Cincinnati Reds have an 81-78 record this season and are sitting in the third place of the NL Central. The Reds have a 36-42 road record and are 58-91 in over/under. They are coming off a 2-1 home victory over the Pirates, that ended their two-game losing streak. Under is 6-1-2 in their last 9 games.
The Reds have a .245 batting average this season, .315 OBP and .391 slugging percentage. Cincinnati’s pitching staff has a 3.88 ERA and 1.22 WHIP. Elly De La Cruz leads the Reds with 163 hits, and in RBI, with 85, while Spencer Steer adds a team-high 21 home runs. Gavin Lux is the team’s best hitter with a .267 batting average.
Zack Littell (R) is the projected starting pitcher for the Reds, and he has a record, 2.88 ERA and 1.15 WHIP.
Cincinnati Reds @ Milwaukee Brewers Betting Trends: September 26, 2025
- Probable Starting Pitcher: Quinn Priester Record this season: 13-2 ERA: 3.25
- Home Record: 7-1
- Last 5 against Reds: 1-0
Why the Milwaukee Brewers will win
- The Brewers have won each of their last nine night games against National League opponents following a road win.
- The Reds have lost 13 of their last 14 games against the Brewers following a win.
- The Reds have failed to cover the run line in each of their last four games.
- The Brewers have covered the run line in each of their last three home games.
- The Reds have trailed after 3 innings in each of their last six Friday night games as road underdogs.
- The Brewers have led after 5 innings in six of their last seven night games at American Family Field against NL Central opponents.
- Probable Starting Pitcher: Zack Littell Record this season: 10-8 ERA: 3.86
- Road Record: 7-4
- Last 5 against Brewers: 0-0
Why the Cincinnati Reds will win
- The underdogs have won each of the Brewers’ last four games.
- The Brewers have lost five of their last six games as favorites against National League opponents.
- The Brewers have failed to cover the run line in each of their last seven games as favorites against National League opponents.
- The Reds have covered the run line in each of their last seven games as underdogs against National League opponents.
- The Brewers have trailed after 5 innings in each of their last five games against NL Central opponents.
- The Brewers have lost the first inning in four of their last five night games against National League opponents.
- The Brewers have trailed after 3 innings in four of their last five games against NL Central opponents.
Total Runs Facts
- Each of the Reds’ last five games as underdogs against NL Central opponents have gone OVER the total runs line.
- Each of the Brewers’ last four games as favorites against the Reds have gone OVER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last five games.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the last six games between the Reds and Brewers at American Family Field.
Milwaukee Brewers Player Prop Facts
- Sal Frelick has recorded at least one hit in each of his last 12 appearances against NL Central opponents.
- Christian Yelich has hit at least one home run in four of his last five appearances after not playing the previous day.
- Andrew Vaughn has recorded a Double in each of his last four appearances after not playing the previous day.
Cincinnati Reds Player Prop Facts
- Spencer Steer has hit at least one home run in three of his last four appearances with the Reds as underdogs against NL Central opponents.
- Jose Trevino has recorded a Double in each of his last three road appearances against NL Central opponents that held a winning record.
- Austin Hays has recorded at least one hit in each of the Reds’ last 10 games as underdogs.
- Elly De La Cruz ranks T6th in the league in Steals (36) this season.
Matchup/League Facts
- The Brewers rank 1st in the league for on-base percentage this season (.333).
- The Brewers rank 2nd in the league for steals this season (161).
- The Reds rank 7th in the league for opponent batting average this season (.234).
- The Reds rank 7th in the league for hits allowed this season (1243).
Reds vs Brewers Prediction
The Brewers are 7-3 in their last 10 meetings against the Reds, and are 3-1 in their last 4 meetings in Milwaukee. Over is 3-1 in their last 4 meetings.
In this Reds vs Brewers Prediction, the Brewers are coming as -165 home favorites. The Reds are still fighting for a Wild Card spot, but the Brewers are putting Priester on the mound, who has been a winning machine this season. On the flip side, Littell takes the mound for the Reds, and he has been in poor form lately, with a 5.14 ERA across his last 5 starts. the Brewers have both a better bullpen and a better offense, and I expect them to get the job here at home.