Reds vs Pirates Prediction 9/24/25 MLB Picks Today

In this article we will formulate a Reds vs Pirates prediction for this MLB game on Wednesday, September 24th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 80-77 this year after they lost game one by a score of 4-2 on Tuesday night. Cincinnati cut the deficit to 4-2 in the second inning, but couldn’t find anymore offense in the loss. The Reds recorded five hits in the game and they were led by De La Cruz, who went 3-3 with one home run and two RBIs in the loss. Cincinnati started Singer, who allowed seven hits and four earned runs over 5.1 innings for the loss, while three pitchers finished the final 3.2 innings in relief. 

Prior to this series, the Reds swept the Cubs in four games and won two out of three against the Cardinals. Cincinnati has won five of their last six games and they are third in the NL Central standings. The Cincinnati pitching staff has a 3.91 ERA with a 1.23 WHIP and a .235 opponent batting average, while their offense has scored 699 runs with a .244 batting average and a .315 on base percentage this season. Elly De La Cruz has led Cincinnati with 21 home runs and 85 RBIs, while Spencer Steer has added 21 home runs and 74 RBIs this year. The projected starting pitcher for Cincinnati is Hunter Greene, who is 7-4 with a 2.74 ERA and a 0.92 WHIP over 101.2 innings pitched this year. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 68-89 this season after they won game one by a score of 4-2 on Tuesday. Pittsburgh scored all four of their runs in the second inning, which was enough to get the low scoring victory. The Pirates recorded eight hits in the game and they were led by Cruz, who went 1-4 with one home run and two RBIs in the win. Pittsburgh started Oviedo, who allowed two hits and two earned runs over 4.2 innings, while Barco got the win and Santana picked up the save. 

Prior to this series, the Pirates won two out of three against the Athletics, but lost all three against the Cubs before that. Pittsburgh has won three games in a row and they are last in the NL Central standings. The Pittsburgh pitching staff has a 3.81 ERA with a 1.22 WHIP and a .236 opponent batting average, while their offense has scored 565 runs with a .231 batting average and a .305 on base percentage this season. Oneil Cruz has led Pittsburgh with 20 home runs and 61 RBIs, while Bryan Reynolds has added 16 home runs and 73 RBIs this year. The projected starting pitcher for Pittsburgh is Paul Skenes, who is 10-10 with a 2.03 ERA and a 0.96 WHIP over 181.2 innings pitched this season. 

Why the Reds will beat the Pirates

Total Runs Facts

Cincinnati Reds Player Prop Facts

Pittsburgh Pirates Player Prop Facts

Matchup/League Facts

Reds vs Pirates Prediction 

Cincinnati had their winning streak snapped on Tuesday night and they took a step back in the wild card race, so they desperately need a win here. The Reds are 44-35 at home this season, while the Pirates are 24-52 on the road. Pittsburgh has won three games in a row and they are starting Skenes, who has allowed a total of four earned runs in his last five starts. Cincinnati is going with Greene, who has allowed two earned runs or fewer in five straight. Skenes is the slightly better pitcher, but I have to side with the Reds lineup at home. 

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