Padres vs Diamondbacks Prediction 9/26/25 MLB Picks Today

The Arizona Diamondbacks and the San Diego Padres meet Friday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Padres vs Diamondbacks Prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Zac Gallen for the start here and Gallen is 13-14 with a 4.70 ERA and 172 strikeouts this season. In his last five starts against San Diego, Gallen is 4-0 with a 1.42 ERA and 37 strikeouts. Yu Darvish will get the start for the Padres here and is 4-5 with a 5.51 ERA and 64 strikeouts this season. In his last five starts against Arizona, Darvish is 2-2 with a 4.94 ERA and 26 strikeouts.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to bounce back from their 8-0 loss at the hands of the Los Angeles Dodgers last time out to fall to 80-79 this season

Diamondbacks Looking To Keep Playoff Hopes Alive

Corbin Carroll has 146 hits with 31 home runs, 84 RBIs, 17 triples and 32 doubles this season. Carroll also has a team-high 32 stolen bases and Geraldo Perdomo has 26 stolen bases as well as 19 home runs and 98 RBIs with a team-high 169 hits this season. Ketel Marte’s added 26 home runs and 70 RBIs as well on the year and Lourdes Gurriel has 124 hits with 24 doubles, 19 home runs and 80 RBIs.

Why the Arizona Diamondbacks will win

Arizona Diamondbacks Player Prop Facts

San Diego Padres Recap

The San Diego Padres come into this game looking to rebound from a 3-1 loss at the hands of the Milwaukee Brewers last time out to sit at 87-72 this season.

Padres Have Four-Game Win Streak Snapped

Manny Machado has 166 hits including a team-high 33 doubles, 26 home runs, 93 RBIs and 14 stolen bases while Fernando Tatis Jr. has 156 hits with 23 home runs and 66 RBIs along with 32 stolen bases of his own this season. Luis Arraez has added 176 hits with 29 doubles, 4 triples, 8 home runs and 61 RBIs while Jackson Merrill’s added 113 hits with 16 home runs and 63 RBIs as well. Xander Bogaerts also has 29 doubles and 20 stolen bases as well this season. Gavin Sheets also has 28 doubles, 19 home runs and 70 RBIs as well this season.

Why the San Diego Padres will win

San Diego Padres Player Prop Facts

Total Runs Facts

Padres vs Diamondbacks Prediction

I’m backing Arizona in this one. I get the case to be made for San Diego here, but Arizona’s the only team fighting for anything right now, as the Padres have clinched. In fairness, Zac Gallen’s been the much better starter in a lot of his recent starts. The Diamondbacks’ bullpen is always going to be a concern in late game situations, but I think Arizona does enough to get the win in this one.

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