The Chicago Cubs and the San Diego Padres meet Wednesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. San Diego Padres prediction.
Starting Pitching Matchup
The Chicago Cubs will send out Kevin Gausman for the start here and Gausman is 9-12 with a 4.51 ERA and 184 strikeouts in the regular season. Nick Pivetta will start for the Padres and was 3-2 with a 2.86 ERA and 42 strikeouts in the regular season.
Chicago Cubs Recap
The Chicago Cubs come into this game looking to bounce back from their 8-0 loss at the hands of the Padres on Tuesday to fall behind 0-1 in the series.
Cubs Looking To Keep Season Alive
Pete Crow-Armstrong leads the Cubs across the board with a team-high 175 hits, 45 home runs, and 107 RBIs alongside 31 doubles and 8 triples so far this season. Nico Hoerner has logged 165 hits with 29 doubles, a triple, 8 home runs, and 72 RBIs, while Alex Bregman has contributed 161 hits with 33 doubles, 2 triples, 28 home runs, and 93 RBIs on the year. Michael Busch has added 145 hits with 27 doubles, 2 triples, 20 home runs, and 77 RBIs, and Ian Happ has recorded 119 hits with 28 doubles, 3 triples, 24 home runs, and 68 RBIs. Carson Kelly has chipped in 98 hits with 15 doubles, 10 home runs, and 58 RBIs, while Dansby Swanson has registered 91 hits with 16 doubles, 3 triples, 19 home runs, and 69 RBIs for Chicago up to this point in the season.
San Diego Padres Recap
The San Diego Padres come into this gae looking to finish the job after Tuesday’s win to draw first blood in the series.
Padres Looking To Avenge 2025 Elimination
Fernando Tatis Jr. leads the Padres with a team-high 181 hits while adding 32 doubles, 3 triples, 25 home runs, and 83 RBIs so far this season. Manny Machado paces San Diego in power, leading the team with 30 home runs and 91 RBIs alongside 128 hits and 22 doubles on the year. Jackson Merrill has contributed 156 hits with 26 doubles, 5 triples, 26 home runs, and 87 RBIs. Xander Bogaerts has logged 120 hits with 18 doubles, a triple, 13 home runs, and 57 RBIs, while Gavin Sheets has chipped in 77 hits with 16 doubles, 17 home runs, and 48 RBIs for the Padres up to this point in the season.
The Chicago Cubs @ San Diego Padres Betting Trends: September 30, 2026
- Probable Starting Pitcher: Nick Pivetta Record this season: 3-2 ERA: 2.86
- Home Record: 3-1
- Last 5 against Cubs: 1-2
Why the San Diego Padres will win
- The Padres have won each of their last nine games as home favorites.
- The Cubs have lost each of their last six road playoff games.
- The Cubs have failed to cover the run line in each of their last eight road playoff games.
- The Padres have covered the run line in each of their last four playoff games as favorites against NL Central opponents.
- The Padres have led after 5 innings in 12 of their last 13 games as favorites.
- The Padres have led after 3 innings in five of their last six playoff games as favorites.
- The Padres have won the first inning in three of their last four games as favorites against the Cubs.
- Probable Starting Pitcher: Kevin Gausman Record this season: 9-12 ERA: 4.51
- Road Record: 4-7
- Last 5 against Padres: 1-1
Why the Chicago Cubs will win
- The Cubs have won five of their last six games as road underdogs against the Padres following a loss.
- The Padres have lost eight of their last 11 games as home favorites against the Cubs following a win.
- The Cubs have covered the run line in 13 of their last 14 games as road underdogs after playing the previous day.
- The Padres have failed to cover the run line in eight of their last nine playoff games following a win.
- The Cubs have led after 5 innings in four of their last five games against NL opponents that held a winning record.
- The Cubs have led after 3 innings in four of their last five games against NL opponents that held a winning record.
Total Runs Facts
- Each of the Padres’ last nine home games have gone OVER the total runs line.
- Four of the Cubs’ last five games as underdogs against the Padres have gone OVER the total runs line.
- There has been no run scored during the first inning in each of Nick Pivetta’s last five appearances as a starter against the Cubs.
- There has been at least one run scored in the first inning in five of the Cubs’ last six games as road underdogs.
San Diego Padres Player Prop Facts
- Nick Pivetta has recorded a win in nine of his last 12 appearances with the Padres as home favorites against NL opponents.
- Fernando Tatis Jr. has hit a home run in three of the Padres’ last four games as favorites.
- Nick Pivetta has recorded seven or more strikeouts in each of his last three appearances against opponents that held a winning record.
- Jackson Merrill has recorded at least one hit in each of the Padres’ last 13 games as favorites.
- Fernando Tatis Jr. ranks 3rd in the league in Hits (181) this season.
Chicago Cubs Player Prop Facts
- Pete Crow-Armstrong has hit a home run in four of the Cubs’ last six games against the Padres.
- Kevin Gausman has recorded six or more strikeouts in each of his last seven appearances against NL opponents.
- Seiya Suzuki has recorded at least one hit in each of his last 10 appearances against the Padres.
- Pete Crow-Armstrong ranks T1st in the league in Home Runs (45) this season.
Matchup/League Facts
- The Padres rank T2nd in the league for steals this season (164).
- The Padres rank 24th in the league for doubles this season (234).
- The Cubs rank 1st in the league for runs scored this season (850).
- The Cubs rank 1st in the league for RBIs this season (804).
Chicago Cubs vs. San Diego Padres Prediction
I’m on the Cubs here. I don’t love Kevin Gausman’s form entering the postseason, but I still think he’s the better option here. Pivetta has been up and down and the Cubs offense has to be better than it was on Tuesday. I’ll back the Cubs here to force a game three.